Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.
J Nat Prod
; 84(2): 537-543, 2021 02 26.
Article
in English
| MEDLINE | ID: covidwho-1104420
ABSTRACT
A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Streptomyces
/
Proton-Translocating ATPases
/
Macrolides
/
Feces
Limits:
Animals
Language:
English
Journal:
J Nat Prod
Year:
2021
Document Type:
Article
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