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Obesity, walking pace and risk of severe COVID-19 and mortality: analysis of UK Biobank.
Yates, Thomas; Razieh, Cameron; Zaccardi, Francesco; Rowlands, Alex V; Seidu, Samuel; Davies, Melanie J; Khunti, Kamlesh.
  • Yates T; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK. ty20@le.ac.uk.
  • Razieh C; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK. ty20@le.ac.uk.
  • Zaccardi F; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Rowlands AV; National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC), NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Seidu S; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
  • Davies MJ; Leicester Real World Evidence Unit, Diabetes Research Centre, University of Leicester, Leicester, UK.
  • Khunti K; Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK.
Int J Obes (Lond) ; 45(5): 1155-1159, 2021 05.
Article in English | MEDLINE | ID: covidwho-1104458
Semantic information from SemMedBD (by NLM)
1. Obesity PREDISPOSES COVID-19
Subject
Obesity
Predicate
PREDISPOSES
Object
COVID-19
2. Obesity PROCESS_OF Persons
Subject
Obesity
Predicate
PROCESS_OF
Object
Persons
3. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
4. Obesity PREDISPOSES COVID-19
Subject
Obesity
Predicate
PREDISPOSES
Object
COVID-19
5. Obesity PROCESS_OF Persons
Subject
Obesity
Predicate
PROCESS_OF
Object
Persons
6. Normal weight PROCESS_OF Persons
Subject
Normal weight
Predicate
PROCESS_OF
Object
Persons
ABSTRACT
Obesity is an emerging risk factor for coronavirus disease-2019 (COVID-19). Simple measures of physical fitness, such as self-reported walking pace, may also be important risk markers. This analysis includes 412,596 UK Biobank participants with linked COVID-19 data (median age at linkage = 68 years, obese = 24%, median number of comorbidities = 1). As of August 24th 2020, there were 1001 cases of severe (in-hospital) disease and 336 COVID-19 deaths. Compared to normal weight individuals, the adjusted odds ratio (OR) of severe COVID-19 in overweight and obese individuals was 1.26 (1.07, 1.48) and 1.49 (1.25, 1.79), respectively. For COVID-19 mortality, the ORs were 1.19 (0.88, 161) and 1.82 (1.33, 2.49), respectively. Compared to those with a brisk walking pace, the OR of severe COVID-19 for steady/average and slow walkers was 1.13 (0.98, 1.31) and 1.88 (1.53, 2.31), respectively. For COVID-19 mortality, the ORs were 1.44 (1.10, 1.90) and 1.83 (1.26, 2.65), respectively. Slow walkers had the highest risk regardless of obesity status. For example, compared to normal weight brisk walkers, the OR of severe disease and COVID-19 mortality in normal weight slow walkers was 2.42 (1.53, 3.84) and 3.75 (1.61, 8.70), respectively. Self-reported slow walkers appear to be a high-risk group for severe COVID-19 outcomes independent of obesity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Walking Speed / COVID-19 / Obesity Subject: Walking Speed / COVID-19 / Obesity Type of study: Etiology study / Risk factors Language: English Journal: Int J Obes (Lond) Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Walking Speed / COVID-19 / Obesity Subject: Walking Speed / COVID-19 / Obesity Type of study: Etiology study / Risk factors Language: English Journal: Int J Obes (Lond) Clinical aspect: Etiology Year: 2021
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