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Exploratory analysis of immunization records highlights decreased SARS-CoV-2 rates in individuals with recent non-COVID-19 vaccinations.
Pawlowski, Colin; Puranik, Arjun; Bandi, Hari; Venkatakrishnan, A J; Agarwal, Vineet; Kennedy, Richard; O'Horo, John C; Gores, Gregory J; Williams, Amy W; Halamka, John; Badley, Andrew D; Soundararajan, Venky.
  • Pawlowski C; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA.
  • Puranik A; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA.
  • Bandi H; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA.
  • Venkatakrishnan AJ; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA.
  • Agarwal V; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA.
  • Kennedy R; Mayo Clinic, Rochester, MN, USA.
  • O'Horo JC; Mayo Clinic, Rochester, MN, USA.
  • Gores GJ; Mayo Clinic, Rochester, MN, USA.
  • Williams AW; Mayo Clinic, Rochester, MN, USA.
  • Halamka J; Mayo Clinic, Rochester, MN, USA.
  • Badley AD; Mayo Clinic, Rochester, MN, USA.
  • Soundararajan V; Nference, Inc., One Main Street, Suite 400, East Arcade, Cambridge, MA, 02142, USA. venky@nference.net.
Sci Rep ; 11(1): 4741, 2021 02 26.
Article in English | MEDLINE | ID: covidwho-1104539
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ABSTRACT
Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SARS-CoV-2 PCR tests. We find that polio, Haemophilus influenzae type-B (HIB), measles-mumps-rubella (MMR), Varicella, pneumococcal conjugate (PCV13), Geriatric Flu, and hepatitis A/hepatitis B (HepA-HepB) vaccines administered in the past 1, 2, and 5 years are associated with decreased SARS-CoV-2 infection rates, even after adjusting for geographic SARS-CoV-2 incidence and testing rates, demographics, comorbidities, and number of other vaccinations. Furthermore, age, race/ethnicity, and blood group stratified analyses reveal significantly lower SARS-CoV-2 rate among black individuals who have taken the PCV13 vaccine, with relative risk of 0.45 at the 5 year time horizon (n 653, 95% CI (0.32, 0.64), p-value 6.9e-05). Overall, this study identifies existing approved vaccines which can be promising candidates for pre-clinical research and Randomized Clinical Trials towards combating COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83641-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-83641-y