Laboratory Predictors of COVID-19 Mortality: A Retrospective Analysis from Tongji Hospital in Wuhan.
Mediators Inflamm
; 2021: 6687412, 2021.
Article
in English
| MEDLINE | ID: covidwho-1105553
ABSTRACT
BACKGROUND:
Novel coronavirus disease 2019 (COVID-19), an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapidly progressed to a global pandemic. Currently, there are limited effective medications approved for this deadly disease.OBJECTIVE:
To investigate the potential predictors of COVID-19 mortality and risk factors for hyperinflammation in COVID-19.METHODS:
Retrospective analysis was carried out in 1,149 patients diagnosed with COVID-19 in Tongji Hospital, Wuhan, China, from 1/13/2020 to 3/15/2020.RESULTS:
We found significant differences in the rates of hyperuricemia (OR 3.17, 95% CI 2.13-4.70; p < 0.001) and hypoalbuminemia (OR 5.68, 95% CI 3.97-8.32; p < 0.001) between deceased and recovered patients. The percentages of hyperuricemia in deceased patients and recovered patients were 23.6% and 8.9%, respectively, which were higher than the reported age-standardized prevalence of 6.2% in Chinese population. Of note, the percentages of both IL-6 and uric acid levels in survived COVID-19 patients were above 90%, suggesting that they might be good specificity for indicators of mortality in COVID-19 patients. The serum level of uric acid (UA) was positively associated with ferritin, TNF-α, and IL-6 but not with anti-inflammatory cytokine IL-10. In addition, the levels of these proinflammatory cytokines in COVID-19 patients showed a trend of reduction after uric acid lowering therapy.CONCLUSIONS:
Our results suggest that uric acid, the end product of purine metabolism, was increased in deceased patients with COVID-19. In addition, the serum level of uric acid was positively associated with inflammatory markers. Uric acid lowering therapy in COVID-19 patients with hyperuricemia may be beneficial.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Uric Acid
/
Pandemics
/
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
Mediators Inflamm
Journal subject:
Biochemistry
/
Pathology
Year:
2021
Document Type:
Article
Affiliation country:
2021
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