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Systematic screening on admission for SARS-CoV-2 to detect asymptomatic infections.
Stadler, Rahel N; Maurer, Laura; Aguilar-Bultet, Lisandra; Franzeck, Fabian; Ruchti, Chantal; Kühl, Richard; Widmer, Andreas F; Schindler, Ruth; Bingisser, Roland; Rentsch, Katharina M; Pargger, Hans; Sutter, Raoul; Steiner, Luzius; Meier, Christoph; Kübler, Werner; Hirsch, Hans H; Egli, Adrian; Battegay, Manuel; Bassetti, Stefano; Tschudin-Sutter, Sarah.
  • Stadler RN; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Maurer L; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Aguilar-Bultet L; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Franzeck F; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Ruchti C; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Kühl R; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Widmer AF; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Schindler R; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Bingisser R; Emergency Department, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Rentsch KM; Laboratory Medicine, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Pargger H; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Sutter R; Intensive Care Unit, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Steiner L; Anesthesiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Meier C; University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kübler W; University Hospital Basel, University of Basel, Basel, Switzerland.
  • Hirsch HH; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
  • Egli A; Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland.
  • Battegay M; Transplantation and Clinical Virology, Department Biomedicine, University of Basel, Basel, Switzerland.
  • Bassetti S; Clinical Microbiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Tschudin-Sutter S; Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Petersgraben 4, 4031, Basel, Switzerland.
Antimicrob Resist Infect Control ; 10(1): 44, 2021 02 27.
Article in English | MEDLINE | ID: covidwho-1105744
ABSTRACT
The proportion of asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains elusive and the potential benefit of systematic screening during the SARS-CoV-2-pandemic is controversial. We investigated the proportion of asymptomatic inpatients who were identified by systematic screening for SARS-CoV-2 upon hospital admission. Our analysis revealed that systematic screening of asymptomatic inpatients detects a low total number of SARS-CoV-2 infections (0.1%), questioning the cost-benefit ratio of this intervention. Even when the population-wide prevalence was low, the proportion of asymptomatic carriers remained stable, supporting the need for universal infection prevention and control strategies to avoid onward transmission by undetected SARS-CoV-2-carriers during the pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Systematic review/Meta Analysis Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Antimicrob Resist Infect Control Year: 2021 Document Type: Article Affiliation country: S13756-021-00912-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asymptomatic Infections / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Systematic review/Meta Analysis Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Antimicrob Resist Infect Control Year: 2021 Document Type: Article Affiliation country: S13756-021-00912-z