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Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19.
Qin, Zhen; Xiang, Kefa; Su, Ding-Feng; Sun, Yang; Liu, Xia.
  • Qin Z; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China.
  • Xiang K; Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, China.
  • Su DF; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China.
  • Sun Y; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China.
  • Liu X; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, China.
Front Immunol ; 11: 595342, 2020.
Article in English | MEDLINE | ID: covidwho-1106024
ABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory pathway. It is evident that nicotine, anisodamine and some herb medicine, activate the CAP and exert anti-inflammation action in vitro and in vivo. As the vagus nerve affects both inflammation and specific immune response, we propose that vagus nerve stimulation by invasive or non-invasive devices and acupuncture at ST36, PC6, or GV20, are also feasible approaches to activate the CAP and control COVID-19. It is worth to investigate the efficacy and safety of the strategy in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vagus Nerve / Neuroimmunomodulation / Vagus Nerve Stimulation / Cytokine Release Syndrome / COVID-19 Topics: Traditional medicine Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.595342

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vagus Nerve / Neuroimmunomodulation / Vagus Nerve Stimulation / Cytokine Release Syndrome / COVID-19 Topics: Traditional medicine Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.595342