Relapse of rare diseases during COVID-19 pandemic: bicytopenia in an adult patient with thiamine-responsive megaloblastic anaemia.
Pan Afr Med J
; 35(Suppl 2): 139, 2020.
Article
in English
| MEDLINE | ID: covidwho-1106485
ABSTRACT
Thiamine-responsive megaloblastic anaemia (TRMA) is a syndrome associated with megaloblastic anaemia, diabetes mellitus and sensorineural deafness, due to mutations in the SLC19A2gene, which codes for a thiamine carrier protein. Oral thiamine supplementation is the main treatment. We report the case of a 19-year-old man known for TRMA, who presented in the emergency department with bicytopenia (haemoglobin 5,4 g/dL, thrombocytes 38×109/L) revealed by dyspnea and chest pain. Investigations excluded bleeding, hemolysis, coagulopathy and iron deficiencies. A recent infection and an acute coronary syndrome have also been eliminated. We later found out that thiamine treatment had been discontinued three months before, due to general confinement in Tunisia during the COVID-19 pandemic. Parenteral administration of 100 mg of thiamine daily resulted in the recovery of haematopoiesis within three weeks.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Thiamine Deficiency
/
Thrombocytopenia
/
Coronavirus Infections
/
Diabetes Mellitus
/
Pandemics
/
Betacoronavirus
/
Hearing Loss, Sensorineural
/
Anemia, Megaloblastic
Type of study:
Case report
/
Diagnostic study
/
Observational study
Limits:
Adult
/
Humans
/
Male
/
Young adult
Country/Region as subject:
Africa
Language:
English
Journal:
Pan Afr Med J
Year:
2020
Document Type:
Article
Affiliation country:
Pamj.supp.2020.35.139.25368
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