Anti-MOG antibody associated demyelination masquerading as COVID-19 encephalopathy?
Developmental Medicine and Child Neurology
; 63(SUPPL 1):96, 2021.
Article
in English
| EMBASE | ID: covidwho-1109507
ABSTRACT
Introduction:
Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disease involving inflammation of the brain and spinal cord, usually triggered by a preceding illness or vaccination. We describe a case triggered by SARSCoV-2. Case A previously healthy 1 year old girl presented with reduced GCS, decorticate posturing, seizures and a 3-day history of fever. She required intubation, was started on intravenous antibiotics, Aciclovir and Levetiracetam and was transferred to PICU. PCR nasal swabs revealed the child was SARSCoV-2 and Adenovirus positive. CSF investigations were normal, including a negative SARSCoV-2 RNA. MRI brain showed bilateral widespread T2 and FLAIR signal changes of subcortical white matter and the splenium. Diffusion restriction with T2/FLAIR signal change was noted in the thalami and pons. This was initially felt to be in keeping with Covid-19 encephalopathy, especially given the presence of the splenial lesion. A spinal MR was normal. She made good progress with steroid therapy and at discharge, was able walk a few steps, recognise voices, clap at nursery rhymes, eat and drink normally, but had cortical visual impairment, which is improving. Her anti-MOG antibodies were later found to be positive, which explains the symmetrical scan changes and brainstem involvement.Discussion:
In literature, there is a paucity of information regarding COVID-19 related encephalopathy. Lesions in the splenium of the corpus callosum appear to be a relatively consistent finding in children with PIMS-TS. Our child did not have any feature to suggest PIMS-TS. It is likely that SARSCoV-2 triggered off an inflammatory process in this child mediated by MOG antibodies.Conclusion:
In the advent of the COVID-19 pandemic, it is important not to attribute clinical findings to SARSCov-2 without excluding other disorders. MOG antibody associated demyelination may mimic the findings described in COVID-19 encephalopathy.
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Developmental Medicine and Child Neurology
Year:
2021
Document Type:
Article
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