Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection?
J Clin Pharm Ther
; 46(5): 1213-1219, 2021 Oct.
Article
in English
| MEDLINE | ID: covidwho-1109555
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Infection by SARS-CoV-2, the virus responsible of COVID-19, is associated with limited treatment options. The purpose of this study was to evaluate the rationale for repurposing functional inhibitors of acid sphingomyelinase (FIASMAs), several of which are approved medicines, for the treatment of SAR-CoV-2 infections.COMMENT:
We propose and discuss the FIASMAs' lysosomotropism as a possible explanation for their observed in vitro activities against viruses, and more specifically against infections caused by coronaviruses such as SARS-CoV-2. Successful in vitro-to-in vivo translation of FIASMAs requires that their pharmacokinetics (dosing regimen and drug-drug interactions) are matched with viral kinetics. WHAT IS NEW ANDCONCLUSION:
Drug repurposing to ensure rapid patient access to effective treatment has garnered much attention in this era of the COVID-19 pandemic. The observed lysosomotropic activity of small-molecule FIASMA compounds suggests that their repurposing as potential drugs against SARS-CoV-2 is promising.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sphingomyelin Phosphodiesterase
/
Drug Repositioning
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
Limits:
Humans
Language:
English
Journal:
J Clin Pharm Ther
Journal subject:
Pharmacy
/
Therapeutics
Year:
2021
Document Type:
Article
Affiliation country:
Jcpt.13390
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