False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases.
Korean J Radiol
; 21(4): 505-508, 2020 04.
Article
in English
| MEDLINE | ID: covidwho-1110277
ABSTRACT
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Reverse Transcriptase Polymerase Chain Reaction
/
Betacoronavirus
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Korean J Radiol
Journal subject:
Radiology
Year:
2020
Document Type:
Article
Affiliation country:
Kjr.2020.0146
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