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Predictive and Prognostic Utility of the Serum Level of Resistin-Like Molecule Beta for Risk Stratification in Patients with Community-Acquired Pneumonia.
Chen, Li; Luo, Qiongzhen; Shang, Ying; He, Xinwei; Xu, Yu; Gao, Zhancheng.
  • Chen L; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
  • Luo Q; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
  • Shang Y; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
  • He X; Department of Internal Medicine, Xicheng District Zhanlanlu Hospital, Beijing 100032, China.
  • Xu Y; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
  • Gao Z; Department of Respiratory & Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
Pathogens ; 10(2)2021 Jan 25.
Article in English | MEDLINE | ID: covidwho-1110464
Semantic information from SemMedBD (by NLM)
1. Community acquired pneumonia PROCESS_OF Patients
Subject
Community acquired pneumonia
Predicate
PROCESS_OF
Object
Patients
2. Patients LOCATION_OF RETNLB gene|RETNLB
Subject
Patients
Predicate
LOCATION_OF
Object
RETNLB gene|RETNLB
3. Community acquired pneumonia AFFECTS Patients
Subject
Community acquired pneumonia
Predicate
AFFECTS
Object
Patients
4. Serum LOCATION_OF RETNLB gene|RETNLB
Subject
Serum
Predicate
LOCATION_OF
Object
RETNLB gene|RETNLB
5. High Level PROCESS_OF Survivors
Subject
High Level
Predicate
PROCESS_OF
Object
Survivors
6. SCAP gene|SCAP PART_OF Patients
Subject
SCAP gene|SCAP
Predicate
PART_OF
Object
Patients
7. Patients LOCATION_OF SCAP gene|SCAP
Subject
Patients
Predicate
LOCATION_OF
Object
SCAP gene|SCAP
8. Community acquired pneumonia PROCESS_OF Patients
Subject
Community acquired pneumonia
Predicate
PROCESS_OF
Object
Patients
9. Patients LOCATION_OF RETNLB gene|RETNLB
Subject
Patients
Predicate
LOCATION_OF
Object
RETNLB gene|RETNLB
10. Community acquired pneumonia AFFECTS Patients
Subject
Community acquired pneumonia
Predicate
AFFECTS
Object
Patients
11. Serum LOCATION_OF RETNLB gene|RETNLB
Subject
Serum
Predicate
LOCATION_OF
Object
RETNLB gene|RETNLB
12. High Level PROCESS_OF Survivors
Subject
High Level
Predicate
PROCESS_OF
Object
Survivors
13. SCAP gene|SCAP PART_OF Patients
Subject
SCAP gene|SCAP
Predicate
PART_OF
Object
Patients
14. Patients LOCATION_OF SCAP gene|SCAP
Subject
Patients
Predicate
LOCATION_OF
Object
SCAP gene|SCAP
ABSTRACT
Despite progress in intensive care, the morbidity and mortality of patients with community-acquired pneumonia (CAP) remains high. Furthermore, the predictive and prognostic utility of resistin-like molecule beta (RELM-ß) in patients with CAP is uncertain. This study investigated the role of RELM-ß in patients with CAP and evaluated its correlation with disease severity and the risk of death. A prospective, multicenter study was conducted in 2017, and admission serum levels of RELM-ß were detected using quantitative enzyme-linked immunosorbent assay. A total of 114 and 112 patients with severe CAP (SCAP) and non-severe CAP (NSCAP) were enrolled, respectively, with 15 healthy controls. Patients with SCAP, especially non-survivors, had significantly higher levels of serum RELM-ß than patients with NSCAP. RELM-ß levels positively correlated with severity scores and consistently predicted SCAP in patients with CAP (area under the curve = 0.794). Increased levels of RELM-ß were closely related to the severity and prognosis of patients with CAP. The accuracy of 30-day mortality predictions of CURB-65 (confusion, urea, respiratory rate, blood pressure, and age ≥ 65 years) can be significantly improved when combined with RELM-ß levels. The level of RELM-ß can assist clinicians in risk stratification of patients with CAP in early stages.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Pathogens10020122

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: Pathogens10020122