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Detection of SARS-coronavirus-2 in the central nervous system of patients with severe acute respiratory syndrome and seizures.
Rezaeitalab, Fariborz; Jamehdar, Saeid Amel; Sepehrinezhad, Ali; Rashidnezhad, Azra; Moradi, Fereydoun; Sadat Esmaeli Fard, Fateme; Hasanzadeh, Sepideh; Etezad Razavi, Mohammad; Gorji, Ali; Sahab Negah, Sajad.
  • Rezaeitalab F; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Jamehdar SA; Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sepehrinezhad A; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Rashidnezhad A; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Moradi F; Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Sadat Esmaeli Fard F; Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hasanzadeh S; Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Etezad Razavi M; Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Gorji A; Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Sahab Negah S; Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Neurovirol ; 27(2): 348-353, 2021 04.
Article in English | MEDLINE | ID: covidwho-1111382
ABSTRACT
This study was designed to evaluate whether severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can directly target the central nervous system (CNS). We present four patients suffering from the loss of consciousness and seizure during the clinical course of COVID-19 infection. In addition to positive nasopharyngeal swab tests, SARS-CoV-2 has been detected in their cerebrospinal fluid. This report indicates the neuroinvasive potential of SARS-CoV-2, suggesting the ability of this virus to spread from the respiratory tract to the CNS.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seizures / Cerebrospinal Fluid / Severe Acute Respiratory Syndrome / SARS-CoV-2 / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Neurovirol Journal subject: Neurology / Virology Year: 2021 Document Type: Article Affiliation country: S13365-020-00938-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Seizures / Cerebrospinal Fluid / Severe Acute Respiratory Syndrome / SARS-CoV-2 / COVID-19 Type of study: Case report / Experimental Studies / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Neurovirol Journal subject: Neurology / Virology Year: 2021 Document Type: Article Affiliation country: S13365-020-00938-w