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Deadly COVID-19 among the elderly: Innate immune memory helping those most in need.
Sohrabi, Yahya; Reinecke, Holger; Joosten, Leo A B; Netea, Mihai G.
  • Sohrabi Y; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • Reinecke H; Institutes of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
  • Joosten LAB; Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • Netea MG; Department of Internal Medicine and Radboud Centre of Infectious Diseases (RCI), Radboud University Medical Centre, Nijmegen, the Netherlands.
Med (N Y) ; 2(4): 378-383, 2021 04 09.
Article in English | MEDLINE | ID: covidwho-1111773
ABSTRACT
Age is a key risk factor associated with the severity of symptoms caused by SARS-CoV-2, and there is an urgent need to reduce COVID-19 morbidity and mortality in elderly individuals. We discuss evidence suggesting that trained immunity elicited by BCG vaccination may improve immune responses and can serve as a strategy to combat COVID-19 in this population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Aged / Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article Affiliation country: J.medj.2021.02.004

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Prognostic study Topics: Vaccines Limits: Aged / Humans Language: English Journal: Med (N Y) Year: 2021 Document Type: Article Affiliation country: J.medj.2021.02.004