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Impact of anxiety, stress and depression related to COVID-19 pandemic on the course of hereditary angioedema with C1-inhibitor deficiency.
Eyice Karabacak, Deniz; Demir, Semra; Yegit, Osman Ozan; Can, Ali; Terzioglu, Kadriye; Ünal, Derya; Olgaç, Müge; Coskun, Raif; Çolakoglu, Bahauddin; Büyüköztürk, Suna; Gelincik, Asli.
  • Eyice Karabacak D; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Demir S; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Yegit OO; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Can A; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Terzioglu K; Kartal Lütfi Kirdar Education and Research Hospital, Adult Immunology and Allergy Clinic, Istanbul, Turkey.
  • Ünal D; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Olgaç M; Sisli Hamidiye Etfal Education and Research Hospital, Adult Immunology and Allergy Clinic, Istanbul, Turkey.
  • Coskun R; Prof Dr Cemil Tasçioglu City Hospital, Adult Immunology and Allergy Clinic, Istanbul, Turkey.
  • Çolakoglu B; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Büyüköztürk S; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Gelincik A; Department of Internal Medicine, Division of Immunology and Allergic Diseases, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Allergy ; 76(8): 2535-2543, 2021 08.
Article in English | MEDLINE | ID: covidwho-1112196
Semantic information from SemMedBD (by NLM)
1. IMPACT gene ASSOCIATED_WITH COVID-19
Subject
IMPACT gene
Predicate
ASSOCIATED_WITH
Object
COVID-19
2. Angioedema PROCESS_OF C0030705
Subject
Angioedema
Predicate
PROCESS_OF
Object
C0030705
3. CD69 protei AFFECTS C0003467
Subject
CD69 protei
Predicate
AFFECTS
Object
C0003467
4. CD69 protei AFFECTS C0011581
Subject
CD69 protei
Predicate
AFFECTS
Object
C0011581
5. CD69 protei AFFECTS C0038435
Subject
CD69 protei
Predicate
AFFECTS
Object
C0038435
6. IMPACT gene ASSOCIATED_WITH COVID-19
Subject
IMPACT gene
Predicate
ASSOCIATED_WITH
Object
COVID-19
7. Angioedemas, Hereditary PROCESS_OF Patients
Subject
Angioedemas, Hereditary
Predicate
PROCESS_OF
Object
Patients
8. CD69 protein, human|CD69 AFFECTS Anxiety
Subject
CD69 protein, human|CD69
Predicate
AFFECTS
Object
Anxiety
9. CD69 protein, human|CD69 AFFECTS Depressive disorder
Subject
CD69 protein, human|CD69
Predicate
AFFECTS
Object
Depressive disorder
10. CD69 protein, human|CD69 AFFECTS Stress
Subject
CD69 protein, human|CD69
Predicate
AFFECTS
Object
Stress
ABSTRACT

BACKGROUND:

Hereditary angioedema (HAE) attacks can be provoked with psychological factors. The aim of this study was to assess the effects of anxiety, depression and stress related to COVID-19 pandemic on disease activity of HAE patients during the quarantine period (QP) and the return to normal period (RTNP).

METHODS:

This study was conducted between March 2020 and September 2020 in four allergy centres. Demographic, clinical features and mental health status were evaluated in QP (from March to the beginning of June) and RTNP (from June to the beginning of September) applied by the government. The 10-point visual analogue scale (VAS10) was used to define the severity of HAE attacks. Depression, Anxiety and Stress Scales-21 (DASS-21) and Fear of COVID-19 (FC-19) scale were performed to assess mental health status.

RESULTS:

139 HAE patients were included in the study. In QP, median attack numbers and median VAS10 scores were 5 (min-max 0-45) and 6 (min-max 0-10), respectively. HAE attack numbers, DASS-21 stress, anxiety, depression and total DASS-21 scores, and FC-19 scores were higher in QP than RTNP (p = 0.001, p < 0.001, p = 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). However, there was no difference in attack severity scores between the two periods (p > 0.05).

CONCLUSIONS:

This study revealed that the restriction measures during COVID-19 outbreak cause an increase in the number of HAE attacks in relation to anxiety, depression, stress and fear of COVID-19 pandemic. Therefore, it is important to provide psychological support to HAE patients during the pandemic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Angioedemas, Hereditary / COVID-19 Type of study: Diagnostic study / Etiology study Limits: Humans Language: English Journal: Allergy Year: 2021 Document Type: Article Affiliation country: All.14796

Full text: Available Collection: International databases Database: MEDLINE Main subject: Angioedemas, Hereditary / COVID-19 Type of study: Diagnostic study / Etiology study Limits: Humans Language: English Journal: Allergy Year: 2021 Document Type: Article Affiliation country: All.14796