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Arterial stiffness in acute COVID-19 and potential associations with clinical outcome.
Schnaubelt, S; Oppenauer, J; Tihanyi, D; Mueller, M; Maldonado-Gonzalez, E; Zejnilovic, S; Haslacher, H; Perkmann, T; Strassl, R; Anders, S; Stefenelli, T; Zehetmayer, S; Koppensteiner, R; Domanovits, H; Schlager, O.
  • Schnaubelt S; From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
  • Oppenauer J; From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
  • Tihanyi D; Department of Pulmonology, Clinic Penzing, Vienna Health Care Group, Vienna, Austria.
  • Mueller M; Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
  • Maldonado-Gonzalez E; Department of Medicine I, Clinic Donaustadt, Vienna Health Care Group, Vienna, Austria.
  • Zejnilovic S; From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
  • Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Strassl R; Division of Clinical Virology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
  • Anders S; Department of Pulmonology, Clinic Penzing, Vienna Health Care Group, Vienna, Austria.
  • Stefenelli T; Department of Medicine I, Clinic Donaustadt, Vienna Health Care Group, Vienna, Austria.
  • Zehetmayer S; Centre for Medical Statistics, Information Technology and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
  • Koppensteiner R; Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
  • Domanovits H; From the, Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
  • Schlager O; Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria.
J Intern Med ; 290(2): 437-443, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1112272
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.

METHODS:

This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.

RESULTS:

Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (ß = 3.164, P = 0.004) and baPWV (ß = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.

CONCLUSION:

COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Stiffness / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: J Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Joim.13275

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vascular Stiffness / COVID-19 Type of study: Observational study / Prognostic study Limits: Aged / Female / Humans / Male Language: English Journal: J Intern Med Journal subject: Internal Medicine Year: 2021 Document Type: Article Affiliation country: Joim.13275