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Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?
Riedel, Rodrigo N; Pérez-Pérez, Antonio; Sánchez-Margalet, Víctor; Varone, Cecilia L; Maymó, Julieta L.
  • Riedel RN; Instituto de Química Biológica (IQUIBICEN), CONICET- Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, 4° piso, 1428, Buenos Aires, Argentina.
  • Pérez-Pérez A; Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Avenida Sánchez Pizjuán 4, 41009, Sevilla, España.
  • Sánchez-Margalet V; Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Hospital Universitario Virgen Macarena, Facultad de Medicina, Universidad de Sevilla, Avenida Sánchez Pizjuán 4, 41009, Sevilla, España.
  • Varone CL; Instituto de Química Biológica (IQUIBICEN), CONICET- Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, 4° piso, 1428, Buenos Aires, Argentina.
  • Maymó JL; Instituto de Química Biológica (IQUIBICEN), CONICET- Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pabellón 2, 4° piso, 1428, Buenos Aires, Argentina. jmaymo@qb.fcen.uba.ar.
Stem Cell Res Ther ; 12(1): 155, 2021 03 01.
Article in English | MEDLINE | ID: covidwho-1112452
ABSTRACT
A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multiple proinflammatory cytokine storm in severe patients. Without effective and safe treatments, COVID-19 has killed thousands of people, becoming a pandemic. Stem cells have been suggested as a therapy for lung-related diseases. In particular, mesenchymal stem cells (MSCs) have been successfully tested in some clinical trials in patients with COVID-19. The encouraging results positioned MSCs as a possible cell therapy for COVID-19. The amniotic membrane from the human placenta at term is a valuable stem cell source, including human amniotic epithelial cells (hAECs) and human mesenchymal stromal cells (hAMSCs). Interestingly, amnion cells have immunoregulatory, regenerative, and anti-inflammatory properties. Moreover, hAECs and hAMSCs have been used both in preclinical studies and in clinical trials against respiratory diseases. They have reduced the inflammatory response and restored the pulmonary tissue architecture in lung injury in vivo models. Here, we review the existing data about the stem cells use for COVID-19 treatment, including the ongoing clinical trials. We also consider the non-cellular therapies that are being applied. Finally, we discuss the human amniotic membrane cells use in patients who suffer from immune/inflammatory lung diseases and hypothesize their possible use as a successful treatment against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stem Cells / Mesenchymal Stem Cell Transplantation / COVID-19 / Amnion Type of study: Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Language: English Journal: Stem Cell Res Ther Year: 2021 Document Type: Article Affiliation country: S13287-021-02216-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Stem Cells / Mesenchymal Stem Cell Transplantation / COVID-19 / Amnion Type of study: Prognostic study / Randomized controlled trials Limits: Female / Humans / Pregnancy Language: English Journal: Stem Cell Res Ther Year: 2021 Document Type: Article Affiliation country: S13287-021-02216-w