Potential mechanisms of action of convalescent plasma in COVID-19.
Diagnosis (Berl)
; 8(4): 413-420, 2021 11 25.
Article
in English
| MEDLINE | ID: covidwho-1112508
ABSTRACT
The COVID-19 pandemic will be remembered as one of the worst catastrophic events in human history. Unfortunately, no universally recognized effective therapeutic agents are currently available for the treatment of severe SARS-CoV-2 infection. In this context, the use of convalescent plasma from recovered COVID-19 patients has gained increasing interest thanks to the initially positive clinical reports. A number of mechanisms of action have been proposed for convalescent plasma, including direct neutralization and suppression of viremia, anti-inflammatory and immunomodulation effects and mitigation of the COVID-19-associated hypercoagulable state. These immune and non-immune mechanisms will be critically discussed in this narrative review.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunization, Passive
/
COVID-19
Type of study:
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Diagnosis (Berl)
Year:
2021
Document Type:
Article
Affiliation country:
Dx-2020-0161
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