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TruScreen detection of cervical tissues for high-risk human papillomavirus-infected women during the COVID-19 pandemic.
Wang, Ziyao; Kang, YaNan; Yu, FuRong; Zhong, Feng-Hui; Huang, Kangni; Zhou, Xuan; Tang, Yunrong; Zhang, Yu; Liou, Yu-Ligh; Ma, Yan.
  • Wang Z; Department of Ultrasound Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan, PR China.
  • Kang Y; Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
  • Yu F; Department of Obstetrics & Gynecology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, PR China.
  • Zhong FH; Department of Obstetrics & Gynecology, Yi Yang Central Hospital, Yiyang, Hunan, PR China.
  • Huang K; Department of Obstetrics & Gynecology, Yi Yang Central Hospital, Yiyang, Hunan, PR China.
  • Zhou X; Hunan Cancer Hospital, Changsha, Hunan, PR China.
  • Tang Y; Scientific Information Management & Analysis Department, Hunan Warm Medical Technology Co. LTD, Loudi, Hunan, PR China.
  • Zhang Y; Department of Gynecology, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
  • Liou YL; Xiangya Medical Laboratory, Central South University, Changsha, Hunan, PR China.
  • Ma Y; The First Affiliated Hospital/School of Clinical Medicine of Guangdong Pharmaceutical University, Guangdong, PR China.
Future Oncol ; 17(10): 1197-1207, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1112570
ABSTRACT

Aims:

To evaluate the efficacy of TruScreen (TS01) for high-risk human papillomavirus (HR-HPV) women compared with other methods in reducing colposcopy referral rates in hospitals.

Methods:

A single-center, prospective, case-control study was conducted from December 2019 to June 2020.

Results:

Among 139 (46.2%) HR-HPV-positive patients, 58 were CIN1, 52 were CIN2-3 and 29 had cervical cancer (n = 29). The sensitivity and specificity of detecting CIN2+ by TS01, colposcopy and HPV16/18 testing were 96.3% and 46.4%, 85.2% and 40.5% and 59.3% and 74.1%, respectively. The highest sensitivity was 96.3% at HPV16/18 and TS01 (each positive results), and the highest specificity was 83.6% at HPV16/18 and TS01 (both positive) for CIN2+ compared with the other methods.

Conclusion:

TS01 is a noninvasive screening method and can be used to diagnose cervical lesions quickly. It is especially suitable as triage tool for HR-HPV-positive women facing SARS-CoV-2 exposure and infection risks in hospital.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / Early Detection of Cancer / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Middle aged / Young adult Language: English Journal: Future Oncol Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Dysplasia / Uterine Cervical Neoplasms / Papillomavirus Infections / Early Detection of Cancer / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Adult / Aged / Female / Humans / Middle aged / Young adult Language: English Journal: Future Oncol Year: 2021 Document Type: Article