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Elevated frequencies of CD14+HLA-DRlo/neg MDSCs in COVID-19 patients.
Xue, GuoHui; Jiang, Mei; Zhao, Rui; Le, AiPing; Li, JunMing.
  • Xue G; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
  • Jiang M; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
  • Zhao R; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
  • Le A; Department of Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
  • Li J; Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi, China.
Aging (Albany NY) ; 13(5): 6236-6246, 2021 02 26.
Article in English | MEDLINE | ID: covidwho-1154948
ABSTRACT

BACKGROUND:

The immune responses, hyper-inflammation or immunosuppression, may be closely related to COVID-19 progression. We aimed to evaluate the changes of frequency of CD14+HLA-DRlo/neg MDSCs, a population of cells with potent immunosuppressive capacity, in COVID-19 patients.

METHODS:

The levels of CD14+HLA-DRlo/neg MDSCs were determined by flow cytometry in 27 COVID-19 patients, and their association with clinical characteristics and laboratory data were analyzed.

RESULTS:

The frequency of CD14+HLA-DRlo/neg MDSCs was elevated in COVID-19 patients, particularly severe patients. A follow-up comparison revealed a decline of CD14+HLA-DRlo/neg MDSCs percentages in most patients 1 day after testing negative for SARS-CoV-2 nucleic acid, but the levels of CD14+HLA-DRlo/neg MDSCs were still greater than 50.0% in 3 ICU patients 4-10 days after negative SARS-CoV-2 results. Elevated frequency of CD14+HLA-DRlo/neg MDSCs was positively correlated with oropharyngeal viral loads and length of hospital stay, while negatively correlated with lymphocyte counts and serum albumin. Moreover, strong correlations were observed between the frequency of CD14+HLA-DRlo/neg MDSCs and T cell subsets, NK cell counts, and B cell percentages. The frequency of CD14+HLA-DRlo/neg MDSCs could be used as a predictor of COVID-19 severity.

CONCLUSIONS:

A high frequency of CD14+HLA-DRlo/neg MDSCs, especially in severe patients, may indicate an immunoparalysis status and could be a predictor of disease severity and prognosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-DR Antigens / Lipopolysaccharide Receptors / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202571

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Full text: Available Collection: International databases Database: MEDLINE Main subject: HLA-DR Antigens / Lipopolysaccharide Receptors / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Aging (Albany NY) Journal subject: Geriatrics Year: 2021 Document Type: Article Affiliation country: Aging.202571