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Comparison of HRCT Chest and RT-PCR in Diagnosis of COVID-19.
Hanif, Nadia; Rubi, Ghazala; Irshad, Nadia; Ameer, Saima; Habib, Uzma; Zaidi, Syed Razi Haider.
  • Hanif N; Department of Radiology, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
  • Rubi G; Department of Central Research Lab, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
  • Irshad N; Department of Radiology, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
  • Ameer S; Department of Radiology, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
  • Habib U; Department of Radiology, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
  • Zaidi SRH; Department of Community Medicine, PGMI / AMC / Lahore General Hospital, Lahore, Pakistan.
J Coll Physicians Surg Pak ; 30(1): S1-S6, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1112938
ABSTRACT

OBJECTIVE:

To compare the diagnostic accuracies of HRCT chest and RT-PCR results in diagnosis of coronavirus disease (COVID-19) in a tertiary care hospital in Lahore. STUDY

DESIGN:

Descriptive study. PLACE AND DURATION OF STUDY Department of Radiology and Central Research Lab, Lahore General Hospital, Lahore, from April to July, 2020.

METHODOLOGY:

Patients aged 18 to 83 years, who had clinically suspected symptoms of COVID-19 (fever, cough/sore throat or shortness of breath) presenting in outpatient or emergency department, were included. These patients had their HRCT chest conducted from Radiology Department and RT-PCR performed at Central Research Lab. These data were retrieved from electronic system of PACS. Results were categorised into positive and negative findings for COVID-19. Diagnostic accuracies of HRCT chest and first RT-PCR along with 95% confidence interval were calculated.

RESULTS:

A total of 94 patients, 55 (58.5%) males and 39 (41.5%) were females. Out of them, 83% patients had positive HRCT chest findings of COVID-19, 17% had negative HRCT chest findings; while 40.4% had positive and 59.6% had negative first PCR. Among the repeat second PCR, 19.6% had negative, 1.8% had positive PCR results; while 78.6% patients didn't undergo repeat PCR. The sensitivity, specificity, NPV, PPV and accuracy of HRCT chest was 92%, 23%, 81%, 45%, and 51%; while of first RT-PCR was 45%, 81%, 23%, 92% and 51%, respectively.

CONCLUSION:

The sensitivity of HRCT chest is higher (92%) as compared to first RT-PCR (45%). Key Words COVID-19, RT-PCR, HRCT chest, Sensitivity, Specificity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, X-Ray Computed / Reverse Transcriptase Polymerase Chain Reaction / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Coll Physicians Surg Pak Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Jcpsp.2021.01.S1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tomography, X-Ray Computed / Reverse Transcriptase Polymerase Chain Reaction / Pandemics / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Coll Physicians Surg Pak Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Jcpsp.2021.01.S1