Predictors of Mortality in Patients with COVID-19 Infection-associated Acute Kidney Injury.
J Coll Physicians Surg Pak
; 30(1): S60-S65, 2021 Jan.
Article
in English
| MEDLINE | ID: covidwho-1112955
ABSTRACT
OBJECTIVE:
To determine clinical characteristics, renal replacement therapy (RRT) requirements, and predictors of mortality in critically ill patients with COVID-19 associated AKI. STUDYDESIGN:
Descriptive study. PLACE AND DURATION OF STUDY Sakarya University Education and Training Hospital, Sakarya, Turkey, between April 1 and 30, 2020.METHODOLOGY:
The study included 55 patients who were admitted with diagnosis of COVID-19, and whose illnesses showed a critical course that leads to AKI. The variables were studied as per objective.RESULTS:
During the follow-up, 43 out of 55 patients (78.2%) died and 12 (21.8%) were discharged with recovery. The mortality was higher in patients at stage 3 (88.9% mortality) compared to stage 2 (53.8% mortality) (p=0.014). In the nonsurvivor group, RDW (red cell distribution width) and albumin levels were lower at admission; whereas, the LDH levels and CRP/albumin ratios were higher. On regression analysis, low albumin level (OR 12.793, p = 0.010), high LDH level (OR 8.454, p = 0.026), and presence of stage 3 AKI (OR 10.268, p = 0.020) were found as independent risk factors for mortality in COVID-19 patients, who developed AKI.CONCLUSION:
In critically ill patients with COVID-19 pneumonia, who developed AKI, it was seen that the presence of low albumin, high LDH, and stage 3 AKI at the time of admission could be used as predictors of mortality. Moreover,, it was shown for the first time that in these patients, the high CRP/albumin ratio and low RDW could be associated with mortality. Key Words Acute kidney injury, Mortality, COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Critical Illness
/
Acute Kidney Injury
/
COVID-19
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
English
Journal:
J Coll Physicians Surg Pak
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Jcpsp.2021.01.S60
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