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The Novel Coronavirus and Haemostatic Abnormalities: Pathophysiology, Clinical Manifestations, and Treatment Recommendations.
Louw, S; Jacobson, B F; Mayne, E S; Wiggill, T M.
  • Louw S; Department of Molecular Medicine and Haematology, National Health Laboratory Service, Johannesburg, South Africa. Susan.louw@nls.ac.za.
  • Jacobson BF; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Susan.louw@nls.ac.za.
  • Mayne ES; Department of Molecular Medicine and Haematology, National Health Laboratory Service, Johannesburg, South Africa.
  • Wiggill TM; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Adv Exp Med Biol ; 1321: 173-180, 2021.
Article in English | MEDLINE | ID: covidwho-1114246
Semantic information from SemMedBD (by NLM)
1. Genus: Coronavirus CAUSES Severe Acute Respiratory Syndrome
Subject
Genus: Coronavirus
Predicate
CAUSES
Object
Severe Acute Respiratory Syndrome
2. SARS coronavirus CAUSES COVID-19
Subject
SARS coronavirus
Predicate
CAUSES
Object
COVID-19
3. Endothelium PART_OF Pulmonary alveolar structure
Subject
Endothelium
Predicate
PART_OF
Object
Pulmonary alveolar structure
4. Endothelium LOCATION_OF Virus
Subject
Endothelium
Predicate
LOCATION_OF
Object
Virus
5. Genus: Coronavirus CAUSES Severe Acute Respiratory Syndrome
Subject
Genus: Coronavirus
Predicate
CAUSES
Object
Severe Acute Respiratory Syndrome
6. SARS coronavirus CAUSES COVID-19
Subject
SARS coronavirus
Predicate
CAUSES
Object
COVID-19
7. Endothelium PART_OF Pulmonary alveolar structure
Subject
Endothelium
Predicate
PART_OF
Object
Pulmonary alveolar structure
8. Endothelium LOCATION_OF Virus
Subject
Endothelium
Predicate
LOCATION_OF
Object
Virus
ABSTRACT
The COVID-19 pandemic, caused by the SARS-C0V-2 virus, was initially considered and managed in a similar manner to the previous SARS epidemic as they are both caused by coronaviruses. What has now become apparent is that a major cause of morbidity and mortality in COVID-19 is abnormal thrombosis. This thrombosis occurs on a macro- and microvascular level and is unique to this disease. The virus has been demonstrated in the endothelium of the pulmonary alveoli and as such is thought to contribute to the devastating respiratory complications encountered. D-dimer concentrations are frequently raised in COVID to levels not frequently seen previously. The optimal anticoagulation treatment in COVID remains to be determined, and the myriad of pathophysiologic effects caused by this virus in the human host have also yet to be fully elucidated.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Hemostatics / Coronavirus / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-59261-5_15

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hemostatics / Coronavirus / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-59261-5_15