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SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma.
Wibmer, Constantinos Kurt; Ayres, Frances; Hermanus, Tandile; Madzivhandila, Mashudu; Kgagudi, Prudence; Oosthuysen, Brent; Lambson, Bronwen E; de Oliveira, Tulio; Vermeulen, Marion; van der Berg, Karin; Rossouw, Theresa; Boswell, Michael; Ueckermann, Veronica; Meiring, Susan; von Gottberg, Anne; Cohen, Cheryl; Morris, Lynn; Bhiman, Jinal N; Moore, Penny L.
  • Wibmer CK; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Ayres F; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Hermanus T; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Madzivhandila M; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Kgagudi P; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Oosthuysen B; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Lambson BE; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • de Oliveira T; Antibody Immunity Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Vermeulen M; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), Department of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, South Africa, Durban, South Africa.
  • van der Berg K; South African National Blood Service, Weltevreden Park, South Africa.
  • Rossouw T; South African National Blood Service, Weltevreden Park, South Africa.
  • Boswell M; Division of Clinical Haematology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
  • Ueckermann V; Department of Immunology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
  • Meiring S; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa.
  • von Gottberg A; Division for Infectious Diseases, Department of Internal Medicine, Steve Biko Academic Hospital and University of Pretoria, Pretoria, South Africa.
  • Cohen C; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Morris L; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
  • Bhiman JN; Department of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Moore PL; National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa.
Nat Med ; 27(4): 622-625, 2021 04.
Article in English | MEDLINE | ID: covidwho-1114719
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ABSTRACT
SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / Immune Evasion / SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01285-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Neutralization Tests / Immune Evasion / SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2021 Document Type: Article Affiliation country: S41591-021-01285-x