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Extra-pulmonary complications of 45 critically ill patients with COVID-19 in Yichang, Hubei province, China: A single-centered, retrospective, observation study.
Wang, Peng; Tan, Xiang; Li, Qian; Qian, Min; Cheng, Aiguo; Ma, Baohua; Wan, Peng; Zhang, Xinli; Guo, Changyun; Sheng, Mengting; Yi, Mengqiu; Yu, Min.
  • Wang P; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Tan X; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Li Q; Department of Pulmonary and Critical Care Medicine, The Third People's Hospital of Yichang, China Three Gorges University Third People's Hospital.
  • Qian M; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Cheng A; Department of Pulmonary and Critical Care Medicine, The Third People's Hospital of Yichang, China Three Gorges University Third People's Hospital.
  • Ma B; Medical Department, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang, Yichang, Hubei, China.
  • Wan P; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Zhang X; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Guo C; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Sheng M; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Yi M; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
  • Yu M; Department of Critical Care Medicine, The People's Hospital of China Three Gorges University, The First People's Hospital of Yichang.
Medicine (Baltimore) ; 100(9): e24604, 2021 Mar 05.
Article in English | MEDLINE | ID: covidwho-1114903
Semantic information from SemMedBD (by NLM)
1. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Pulmonary Complication PROCESS_OF Patients
Subject
Pulmonary Complication
Predicate
PROCESS_OF
Object
Patients
4. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Pulmonary Complication PROCESS_OF Patients
Subject
Pulmonary Complication
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
ABSTRACT Mortality of critically ill patients with coronavirus disease 2019 (COVID-19) was high. Aims to examine whether time from symptoms onset to intensive care unit (ICU) admission affects incidence of extra-pulmonary complications and prognosis in order to provide a new insight for reducing the mortality. A single-centered, retrospective, observational study investigated 45 critically ill patients with COVID-19 hospitalized in ICU of The Third People's Hospital of Yichang from January 17 to March 29, 2020. Patients were divided into 2 groups according to time from symptoms onset to ICU admission (>7 and ≤7 days) and into 2 groups according to prognosis (survivors and non-survivors). Epidemiological, clinical, laboratory, radiological characteristics and treatment data were studied. Compared with patients who admitted to the ICU since symptoms onset ≤7 days (55.6%), patients who admitted to the ICU since symptoms onset >7 days (44.4%) were more likely to have extra-pulmonary complications (19 [95.0%] vs 16 [64.0%], P = .034), including acute kidney injury, cardiac injury, acute heart failure, liver dysfunction, gastrointestinal hemorrhage, hyperamylasemia, and hypernatremia. The incidence rates of acute respiratory distress syndrome, pneumothorax, and hospital-acquired pneumonia had no difference between the 2 groups. Except activated partial thromboplastin and Na+ concentration, the laboratory findings were worse in group of time from symptoms onset to ICU admission >7 days. There was no difference in mortality between the 2 groups. Of the 45 cases in the ICU, 19 (42.2%) were non-survivors, and 16 (35.6%) were with hospital-acquired pneumonia. Among these non-survivors, hospital-acquired pneumonia was up to 12 (63.2%) besides higher incidence of extra-pulmonary complications. However, hospital-acquired pneumonia occurred in only 4 (15.4%) survivors. Critically ill patients with COVID-19 who admitted to ICU at once might get benefit from intensive care via lower rate of extra-pulmonary complications.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / Critical Care / Symptom Assessment / Time-to-Treatment / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / Critical Care / Symptom Assessment / Time-to-Treatment / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Randomized controlled trials / Risk factors Limits: Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article