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Two-months quality of life of COVID-19 invasively ventilated survivors; an Italian single-center study.
Monti, Giacomo; Leggieri, Carlo; Fominskiy, Evgeny; Scandroglio, Anna Mara; Colombo, Sergio; Tozzi, Margherita; Moizo, Elena; Mucci, Milena; Crivellari, Martina; Pieri, Marina; Guzzo, Francesca; Piemontese, Simona; De Lorenzo, Rebecca; Da Prat, Valentina; Fedrizzi, Monica; Faustini, Carolina; Di Piazza, Martina; Conte, Francesca; Lembo, Rosalba; Esposito, Antonio; Dagna, Lorenzo; Landoni, Giovanni; Zangrillo, Alberto.
  • Monti G; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Leggieri C; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Fominskiy E; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Scandroglio AM; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Colombo S; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Tozzi M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Moizo E; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Mucci M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Crivellari M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Pieri M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Guzzo F; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Piemontese S; IRCCS San Raffaele Scientific Institute, Hematology and Bone Marrow Transplant Unit, Milan, Italy.
  • De Lorenzo R; Department of Internal Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Da Prat V; General Medicine and Advanced Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Fedrizzi M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Faustini C; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Di Piazza M; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Conte F; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Lembo R; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Esposito A; IRCCS San Raffaele Scientific Institute, Clinical and Experimental Radiology Unit, Experimental Imaging Centre, Milan, Italy.
  • Dagna L; IRCCS San Raffaele Scientific Institute, Medicine and Clinical Immunology, Milan, Italy.
  • Landoni G; Department of Anaesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Zangrillo A; Vita-Salute University San Raffaele, Milano, Italia, Anesthesia and Intensive Care, Milan, Italy.
Acta Anaesthesiol Scand ; 65(7): 912-920, 2021 08.
Article in English | MEDLINE | ID: covidwho-1114984
ABSTRACT

BACKGROUND:

COVID-19 disease can lead to severe functional impairments after discharge. We assessed the quality of life of invasively ventilated COVID-19 ARDS survivors.

METHODS:

We carried out a prospective follow-up study of the patients admitted to the Intensive Care Units (ICUs) of a teaching hospital. Patients affected by COVID-19 ARDS who required invasive ventilation and were successfully discharged home were assessed through the telephone administration of validated tests. We explored survival, functional outcomes, return to work, quality of life, cognitive and psychological sequelae. The main variables of interest were the following demographics, severity scores, laboratory values, comorbidities, schooling, working status, treatments received during ICU stay, complications, and psychological, cognitive, functional outcomes.

RESULTS:

Out of 116 consecutive invasively ventilated patients, overall survival was 65/116 (56%) with no death occurring after hospital discharge. Forty-two patients were already discharged home with a median follow-up time of 61 (51-71) days after ICU discharge and 39 of them accepted to be interviewed. Only one patient (1/39) experienced cognitive decline. The vast majority of patients reported no difficulty in walking (32/3582%), self-care (33/3985%), and usual activities (30/3978%). All patients were either malnourished (15/3938%) or at risk for malnutrition (24/3962%). Exertional dyspnea was present in 20/39 (51%) patients. 19/39 (49%) reported alterations in senses of smell and/or taste either before or after hospitalization.

CONCLUSIONS:

Invasively ventilated COVID-19 ARDS survivors have an overall good recovery at a 2-months follow-up which is better than what was previously reported in non-COVID-19 ARDS patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Respiration, Artificial / Survivors / Recovery of Function / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13812

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quality of Life / Respiration, Artificial / Survivors / Recovery of Function / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Acta Anaesthesiol Scand Year: 2021 Document Type: Article Affiliation country: Aas.13812