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Development of General Methods for Detection of Virus by Engineering Fluorescent Silver Nanoclusters.
Li, Dan; Chen, Hui; Gao, Xianhui; Mei, Xifan; Yang, Liqun.
  • Li D; Department of Basic Science, Jinzhou Medical University, Jinzhou 121001, China.
  • Chen H; Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
  • Gao X; College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
  • Mei X; Department of Basic Science, Jinzhou Medical University, Jinzhou 121001, China.
  • Yang L; Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China.
ACS Sens ; 6(3): 613-627, 2021 03 26.
Article in English | MEDLINE | ID: covidwho-1116121
ABSTRACT
Viruses have caused significant damage to the world. Effective detection is required to relieve the impact of viral infections. A biomolecule can be used as a template such as deoxyribonucleic acid (DNA), peptide, or protein, for the growth of silver nanoclusters (AgNCs) and for recognizing a virus. Both the AgNCs and the recognition elements are tunable, which is promising for the analysis of new viruses. Considering that a new virus such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently requires a facile sensing strategy, various virus detection strategies based on AgNCs including fluorescence enhancement, color change, quenching, and recovery are summarized. Particular emphasis is placed on the molecular analysis of viruses using DNA stabilized AgNCs (DNA-AgNCs), which detect the virus's genetic material. The more widespread applications of AgNCs for general virus detection are also discussed. Further development of these technologies may address the challenge for facile detection of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Silver / Viruses / DNA, Viral / Biosensing Techniques / Metal Nanoparticles Limits: Humans Language: English Journal: ACS Sens Year: 2021 Document Type: Article Affiliation country: Acssensors.0c02322

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Silver / Viruses / DNA, Viral / Biosensing Techniques / Metal Nanoparticles Limits: Humans Language: English Journal: ACS Sens Year: 2021 Document Type: Article Affiliation country: Acssensors.0c02322