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Chemodynamic features of nanoparticles: Application to understanding the dynamic life cycle of SARS-CoV-2 in aerosols and aqueous biointerfacial zones.
Duval, Jérôme F L; van Leeuwen, Herman P; Norde, Willem; Town, Raewyn M.
  • Duval JFL; Université de Lorraine, CNRS, LIEC, F-54000 Nancy, France.
  • van Leeuwen HP; Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4, 6708, WE, Wageningen, the Netherlands.
  • Norde W; Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4, 6708, WE, Wageningen, the Netherlands.
  • Town RM; Physical Chemistry and Soft Matter, Wageningen University & Research, Stippeneng 4, 6708, WE, Wageningen, the Netherlands; Systemic Physiological and Ecotoxicological Research (SPHERE), Department of Biology, Universiteit Antwerpen, Groenenborgerlaan 171, 2020 Antwerpen, Belgium.. Electronic add
Adv Colloid Interface Sci ; 290: 102400, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1116130
ABSTRACT
We review concepts involved in describing the chemodynamic features of nanoparticles and apply the framework to gain physicochemical insights into interactions between SARS-CoV-2 virions and airborne particulate matter (PM). Our analysis is highly pertinent given that the World Health Organisation acknowledges that SARS-CoV-2 may be transmitted by respiratory droplets, and the US Center for Disease Control and Prevention recognises that airborne transmission of SARS-CoV-2 can occur. In our theoretical treatment, the virion is assimilated to a core-shell nanoparticle, and contributions of various interaction energies to the virion-PM association (electrostatic, hydrophobic, London-van der Waals, etc.) are generically included. We review the limited available literature on the physicochemical features of the SARS-CoV-2 virion and identify knowledge gaps. Despite the lack of quantitative data, our conceptual framework qualitatively predicts that virion-PM entities are largely able to maintain equilibrium on the timescale of their diffusion towards the host cell surface. Comparison of the relevant mass transport coefficients reveals that virion biointernalization demand by alveolar host cells may be greater than the diffusive supply. Under such conditions both the free and PM-sorbed virions may contribute to the transmitted dose. This result points to the potential for PM to serve as a shuttle for delivery of virions to host cell targets. Thus, our critical review reveals that the chemodynamics of virion-PM interactions may play a crucial role in the transmission of COVID-19, and provides a sound basis for explaining reported correlations between episodes of air pollution and outbreaks of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virion / Epithelial Cells / Particulate Matter / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Qualitative research / Reviews Limits: Humans Language: English Journal: Adv Colloid Interface Sci Journal subject: Chemistry Year: 2021 Document Type: Article Affiliation country: J.cis.2021.102400

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virion / Epithelial Cells / Particulate Matter / SARS-CoV-2 / COVID-19 Type of study: Prognostic study / Qualitative research / Reviews Limits: Humans Language: English Journal: Adv Colloid Interface Sci Journal subject: Chemistry Year: 2021 Document Type: Article Affiliation country: J.cis.2021.102400