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The Unyvero Hospital-Acquired pneumonia panel for diagnosis of secondary bacterial pneumonia in COVID-19 patients.
Tellapragada, Chaitanya; Giske, Christian G.
  • Tellapragada C; Divison of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Alfred Nobels Allé 8, 14183, Stockholm, Sweden. Chaitanya.tellapragada@ki.se.
  • Giske CG; Divison of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Alfred Nobels Allé 8, 14183, Stockholm, Sweden.
Eur J Clin Microbiol Infect Dis ; 40(12): 2479-2485, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1116614
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ABSTRACT
The study was undertaken to evaluate the performance of Unyvero Hospitalized Pneumonia (HPN) panel application, a multiplex PCR-based method for the detection of bacterial pathogens from lower respiratory tract (LRT) samples, obtained from COVID-19 patients with suspected secondary hospital-acquired pneumonia. Residual LRT samples obtained from critically ill COVID-19 patients with predetermined microbiological culture results were tested using the Unyvero HPN Application. Performance evaluation of the HPN Application was carried out using the standard-of-care (SoC) microbiological culture findings as the reference method. Eighty-three LRT samples were used in the evaluation. The HPN Application had a full concordance with SoC findings in 59/83 (71%) samples. The new method detected additional bacterial species in 21 (25%) and failed at detecting a bacterial species present in lower respiratory culture in 3 (3.6%) samples. Overall the sensitivity, specificity, positive, and negative predictive values of the HPN Application were 95.1% (95%CI 96.5-98.3%), 98.3% (95% CI 97.5-98.9%), 71.6% (95% CI 61.0-80.3%), and 99.8% (95% CI 99.3-99.9%), respectively. In conclusion, the HPN Application demonstrated higher diagnostic yield in comparison with the culture and generated results within 5 h.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacteria / Cross Infection / Pneumonia, Bacterial / Multiplex Polymerase Chain Reaction / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-021-04194-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Bacteria / Cross Infection / Pneumonia, Bacterial / Multiplex Polymerase Chain Reaction / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2021 Document Type: Article Affiliation country: S10096-021-04194-6