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Application of a portable instrument for rapid and reliable detection of SARS-CoV-2 infection in any environment.
Martinelli, Federico; Perrone, Anna; Della Noce, Isabella; Colombo, Lorenzo; Lo Priore, Stefano; Romano, Simone.
  • Martinelli F; Department of Biology, Università degli studi di Firenze, Firenze, Italy.
  • Perrone A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
  • Della Noce I; Lower Ground Floor, Hyris Limited, London, UK.
  • Colombo L; Lower Ground Floor, Hyris Limited, London, UK.
  • Lo Priore S; Lower Ground Floor, Hyris Limited, London, UK.
  • Romano S; Lower Ground Floor, Hyris Limited, London, UK.
Immunol Rev ; 295 Suppl s1: 4-10, 2020 05.
Article in English | MEDLINE | ID: covidwho-1116789
ABSTRACT
The ongoing outbreak of the novel coronavirus (SARS-CoV-2) infection is creating serious challenges for health laboratories that seek to identify viral infections as early as possible, optimally at the earliest appearance of symptom. Indeed, there is urgent need to develop and deploy robust diagnostic methodologies not only to use in health laboratory environments but also directly in places where humans circulate and spread the virus such as airports, trains, boats, and any public aggregation places. The success of a reliable and sensitive asymptomatic diagnosis relies on the identification and measurement of informative biomarkers from human host and virus in a rapid, sensitive, and inexpensive manner. The objective of this article is to describe an innovative multidisciplinary approach to develop an efficient, inexpensive, and easy-to-use portable instrument (bCUBE® by Hyris Ltd) that can be employed as a surveillance system for the emergency caused by SARS-CoV-2. A solution for Coronavirus testing, compliant with CDC guidelines, is scheduled to be released in the next weeks. In addition, we will describe a workflow and path of an integrated multi-omic approach that will lead to host and pathogen biomarker discovery in order to train the instrument to provide reliable results based on a specific biomarker's fingerprint of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Screening / Disease Outbreaks / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Immunol Rev Year: 2020 Document Type: Article Affiliation country: Imr.12857

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mass Screening / Disease Outbreaks / Coronavirus Infections / Clinical Laboratory Techniques / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Immunol Rev Year: 2020 Document Type: Article Affiliation country: Imr.12857