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SARS-CoV-2-associated first episode of acute mania with psychotic features.
Sen, Meltem; Yesilkaya, Umit Haluk; Balcioglu, Yasin Hasan.
  • Sen M; Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.
  • Yesilkaya UH; Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.
  • Balcioglu YH; Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey. Electronic address: yhasanbalcioglu@gmail.com.
J Clin Neurosci ; 87: 29-31, 2021 May.
Article in English | MEDLINE | ID: covidwho-1116965
ABSTRACT
Despite neuropsychiatric outcomes of SARS-CoV-2 infection are now under close scrutiny, psychoneuroimmunological characteristics of COVID-19 and precise pathophysiology of neuropsychiatric manifestations of the infection are still obscure. Moreover, there still exists a shortfall in demonstrating specific clinical manifestations of the brain involvement of the virus. Here, we presented a 33-year-old female patient with COVID-19, reporting acute-onset paranoid delusions symptoms, insomnia and irritability. Cranial MRI showed an hyperintense signal in the splenium of the corpus callosum with decreased apparent diffusion coefficient, which might possibly indicate the presence of cytotoxic edema related to the brain involvement of the infection. Following the completion of SARS-CoV-2 treatment, both cytotoxic edema and psychiatric symptoms resolved. In light of this report, we suggest that either heightened immune response and direct viral infection that SARS-CoV-2 may lead to such psychiatric manifestations and neuropsychiatric monitoring should be performed in patients with COVID-19. Prompt recognition of psychiatric consequences of COVID-19 may help clinicians provide guidance for differential diagnosis and manage them accordingly.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Psychotic Disorders / Mania / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Clin Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: J.jocn.2021.02.012

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Psychotic Disorders / Mania / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study / Qualitative research Topics: Long Covid Limits: Adult / Female / Humans Language: English Journal: J Clin Neurosci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: J.jocn.2021.02.012