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Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 May Be Predictive of Death in Severe Coronavirus Disease 2019.
Bowman, Emily R; Cameron, Cheryl M Ainslie; Avery, Ann; Gabriel, Janelle; Kettelhut, Aaren; Hecker, Michelle; Sontich, Claudia Ute; Tamilselvan, Banumathi; Nichols, Carmen N; Richardson, Brian; Cartwright, Michael; Funderburg, Nicholas T; Cameron, Mark J.
  • Bowman ER; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, USA.
  • Cameron CMA; Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, USA.
  • Avery A; Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, Ohio, USA.
  • Gabriel J; School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Kettelhut A; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, USA.
  • Hecker M; School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, Ohio State University, Columbus, Ohio, USA.
  • Sontich CU; Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, Ohio, USA.
  • Tamilselvan B; School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
  • Nichols CN; Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, Ohio, USA.
  • Richardson B; Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, USA.
  • Cartwright M; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
  • Funderburg NT; Department of Nutrition, Case Western Reserve University, Cleveland, Ohio, USA.
  • Cameron MJ; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
J Infect Dis ; 223(5): 805-810, 2021 03 03.
Article in English | MEDLINE | ID: covidwho-1117029
ABSTRACT
People infected with severe acute respiratory syndrome coronavirus 2 display a wide range of illness, from asymptomatic infection to severe respiratory distress resulting in death. We measured serum biomarkers in uninfected individuals and in individuals with mild, moderate, or critical coronavirus disease 2019 (COVID-19) disease. Levels of monocyte activation (soluble CD14 and fatty acid-binding protein 4) and inflammation (tumor necrosis factor receptors 1 and 2 [TNFR1 and TNFR2]) were increased in COVID-19 individuals, regardless of disease severity. Among patients with critical disease, individuals who recovered from COVID-19 had lower levels of TNFR1 and TNFR2 at hospital admission compared to these levels in patients with critical disease who ultimately died.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipopolysaccharide Receptors / Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipopolysaccharide Receptors / Receptors, Tumor Necrosis Factor, Type I / Receptors, Tumor Necrosis Factor, Type II / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Infect Dis Year: 2021 Document Type: Article Affiliation country: Infdis