The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism.

Tanner, Caroline M; Cummings, Steven R; Schwarzschild, Michael A; Brown, Ethan G; Dorsey, E Ray; Espay, Alberto J; Galifianakis, Nicholas B; Goldman, Samuel M; Litvan, Irene; Luthra, Nijee; McFarland, Nikolaus R; Mitchell, Kyle T; Standaert, David G; Bauer, Douglas C; Greenspan, Susan L; Beck, James C; Lyles, Kenneth W

Tanner, Caroline M; Cummings, Steven R; Schwarzschild, Michael A; Brown, Ethan G; Dorsey, E Ray; Espay, Alberto J; Galifianakis, Nicholas B; Goldman, Samuel M; Litvan, Irene; Luthra, Nijee; McFarland, Nikolaus R; Mitchell, Kyle T; Standaert, David G; Bauer, Douglas C; Greenspan, Susan L; Beck, James C; Lyles, Kenneth W.

Tanner CM; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. caroline.tanner@ucsf.edu.
Cummings SR; Parkinson's Disease Research Education and Clinical Center, San Francisco Veteran's Affairs Health Care System, San Francisco, CA, USA. caroline.tanner@ucsf.edu.
Schwarzschild MA; San Francisco Coordinating Center,California Pacific Medical Center Research Institute, Departments of Medicine and Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Brown EG; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Dorsey ER; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Espay AJ; Center for Health + Technology and Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.
Galifianakis NB; James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA.
Goldman SM; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Litvan I; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Luthra N; Division of Occupational and Environmental Medicine, University of California San Francisco, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
McFarland NR; Parkinson and Other Movement Disorders Center, Department of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Mitchell KT; Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Standaert DG; Norman Fixel Institute for Neurological Diseases, Department of Neurology, University of Florida College of Medicine, Gainesville, FL, USA.
Bauer DC; Department of Neurology, Duke University School of Medicine, Durham, NC, USA.
Greenspan SL; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, USA.
Beck JC; Departments of Medicine and Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Lyles KW; Osteoporosis Prevention and Treatment Center, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

NPJ Parkinsons Dis ; 7(1): 16, 2021 Mar 01.

Article in English | MEDLINE | ID: covidwho-1117390

ABSTRACT

ABSTRACT

The Trial of Parkinson's And Zoledronic acid (TOPAZ, https//clinicaltrials.gov/ct2/show/NCT03924414 ) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral treatment for osteoporosis, for fracture prevention in people with neurodegenerative parkinsonism. Aiming to enroll 3,500 participants age 65 years or older, TOPAZ is one of the largest randomized, placebo-controlled clinical trials ever attempted in parkinsonism. The feasibility of TOPAZ is enhanced by its design as a U.S.- wide home-based trial without geographical limits. Participants receive information from multiple sources, including specialty practices, support groups and websites. Conducting TOPAZ in participants' homes takes advantage of online consent technology, the capacity to confirm diagnosis using telemedicine and the availability of research nursing to provide screening and parenteral therapy in homes. Home-based clinical research may provide an efficient, convenient, less expensive method that opens participation in clinical trials to almost anyone with parkinsonism.

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: NPJ Parkinsons Dis Year: 2021 Document Type: Article Affiliation country: S41531-021-00162-1

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