Nanoparticle-Mediated Cytoplasmic Delivery of Messenger RNA Vaccines: Challenges and Future Perspectives.
Pharm Res
; 38(3): 473-478, 2021 Mar.
Article
in English
| MEDLINE | ID: covidwho-1117456
ABSTRACT
The COVID-19 pandemic has left scientists and clinicians no choice but a race to find solutions to save lives while controlling the rapid spreading. Messenger RNA (mRNA)-based vaccines have become the front-runners because of their safety profiles, precise and reproducible immune response with more cost-effective and faster production than other types of vaccines. However, the physicochemical properties of naked mRNA necessitate innovative delivery technologies to ferry these 'messengers' to ribosomes inside cells by crossing various barriers and subsequently induce an immune response. Intracellular delivery followed by endosomal escape represents the key strategies for cytoplasmic delivery of mRNA vaccines to the target. This Perspective provides insights into how state-of-the-art nanotechnology helps break the delivery barriers and advance the development of mRNA vaccines. The challenges remaining and future perspectives are outlined.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ribosomes
/
Drug Carriers
/
Vaccines, Synthetic
/
Cytoplasm
/
Nanoparticles
/
COVID-19 Vaccines
/
COVID-19
/
Lipids
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
Pharm Res
Year:
2021
Document Type:
Article
Affiliation country:
S11095-021-03015-x
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