Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance.
PLoS Comput Biol
; 17(3): e1008726, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-1117464
ABSTRACT
We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the RT-qPCR process used to test for the presence of virus in a sample and construct a statistical model for the viral load in a typical infected individual inspired by large-scale clinical datasets. We present an application of group testing for the prevention of epidemic outbreak in closed connected communities. We then propose a method for the measure of the prevalence in a population taking into account the increased number of false negatives associated with the group testing method.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Population Surveillance
/
Epidemiological Monitoring
/
COVID-19 Testing
/
SARS-CoV-2
/
COVID-19
/
Group Processes
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
PLoS Comput Biol
Journal subject:
Biology
/
Medical Informatics
Year:
2021
Document Type:
Article
Affiliation country:
Journal.pcbi.1008726
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