Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care.

Pillon, Nicolas J; Loos, Ruth J F; Marshall, Sally M; Zierath, Juleen R

Pillon, Nicolas J; Loos, Ruth J F; Marshall, Sally M; Zierath, Juleen R.

Pillon NJ; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Marshall SM; Diabetes Research Group, Translational and Clinical Research Institute, Faculty of Clinical Medical Sciences, Newcastle University, 4(th) Floor William Leech Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
Zierath JR; Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Cell ; 184(6): 1530-1544, 2021 03 18.

Article in English | MEDLINE | ID: covidwho-1118348

ABSTRACT

ABSTRACT

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.

Subject(s)

COVID-19/epidemiology; Diabetes Mellitus, Type 2/epidemiology; Diabetes Mellitus, Type 2/therapy; Obesity/epidemiology; Obesity/therapy; Pandemics; Precision Medicine/methods; SARS-CoV-2; COVID-19/virology; Circadian Rhythm; Diabetes Mellitus, Type 2/genetics; Diabetes Mellitus, Type 2/metabolism; Epigenesis, Genetic; Genetic Predisposition to Disease; Humans; Inflammation/immunology; Inflammation/metabolism; Obesity/genetics; Obesity/metabolism; Prevalence; Risk Factors; Thermotolerance

Keywords

circadian clock; diet; environment; exercise; genetics; inflammation; metabolism; personalized medicine; thermal regulation; treatment

Fulltext

XML

PubMed Links

Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Precision Medicine / Pandemics / SARS-CoV-2 / COVID-19 / Obesity Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Cell Year: 2021 Document Type: Article Affiliation country: J.cell.2021.02.012

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

PubMed Links

Search on Google