Analysis of microparticle deposition in the human lung by taguchi method and response surface methodology.
Environ Res
; 197: 110975, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1118425
ABSTRACT
The deposition phenomenon of microparticle and SAR-CoV-2 laced bioaerosol in human airways is studied by Taguchi methods and response surface methodology (RSM). The data used herein is obtained from simulations of airflow dynamics and deposition fractions of drug particle aerosols in the downstream airways of asthma patients using computational fluid dynamics (CFD) and discrete particle motion (DPM). Three main parameters, including airflow rate, drug dose, and particle size, affecting aerosol deposition in the lungs of asthma patients are examined. The highest deposition fraction (DF) is obtained at the flow rate of 45 L min-1, the drug dose of 200 µg·puff-1, and the particle diameter of 5 µm. The optimized combination of levels for the three parameters for maximum drug deposition is performed via the Taguchi method. The importance of the influencing factors rank as particle size > drug dose > flow rate. RSM reveals that the combination of 30 L min-1, 5 µm, 200 µg·puff- has the highest deposition fraction. In part, this research also studied the deposition of bioaerosols contaminated with the SAR-CoV-2 virus, and their lowest DF is 1.15%. The low DF of bioaerosols reduces the probability of the SAR-CoV-2 virus transmission.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hydrodynamics
/
Lung
Limits:
Humans
Language:
English
Journal:
Environ Res
Year:
2021
Document Type:
Article
Affiliation country:
J.envres.2021.110975
Similar
MEDLINE
...
LILACS
LIS