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Chronic Respiratory Diseases and the Outcomes of COVID-19: A Nationwide Retrospective Cohort Study of 39,420 Cases.
Guan, Wei-Jie; Liang, Wen-Hua; Shi, Ying; Gan, Lan-Xia; Wang, Hai-Bo; He, Jian-Xing; Zhong, Nan-Shan.
  • Guan WJ; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
  • Liang WH; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory
  • Shi Y; China Standard Medical Information Research Center, Shenzhen, China.
  • Gan LX; China Standard Medical Information Research Center, Shenzhen, China.
  • Wang HB; Clinical Trial Unit, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. Electronic address: drjianxing.he@gmail.com.
  • He JX; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China; Department of Thoracic Oncology and Surgery, State Key Laboratory of Respiratory
  • Zhong NS; State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
J Allergy Clin Immunol Pract ; 9(7): 2645-2655.e14, 2021 07.
Article in English | MEDLINE | ID: covidwho-1118526
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Chronic disease of respiratory system PROCESS_OF Patients
Subject
Chronic disease of respiratory system
Predicate
PROCESS_OF
Object
Patients
3. Chronic Obstructive Airway Disease PRECEDES Bronchiectasis
Subject
Chronic Obstructive Airway Disease
Predicate
PRECEDES
Object
Bronchiectasis
4. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
Patients
5. Reaching NEG_PROCESS_OF Patients
Subject
Reaching
Predicate
NEG_PROCESS_OF
Object
Patients
6. Reaching ASSOCIATED_WITH Chronic disease of respiratory system
Subject
Reaching
Predicate
ASSOCIATED_WITH
Object
Chronic disease of respiratory system
7. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
8. Chronic disease of respiratory system PROCESS_OF Patients
Subject
Chronic disease of respiratory system
Predicate
PROCESS_OF
Object
Patients
9. Chronic Obstructive Airway Disease PRECEDES Bronchiectasis
Subject
Chronic Obstructive Airway Disease
Predicate
PRECEDES
Object
Bronchiectasis
10. Chronic Obstructive Airway Disease PROCESS_OF Patients
Subject
Chronic Obstructive Airway Disease
Predicate
PROCESS_OF
Object
Patients
11. Reaching NEG_PROCESS_OF Patients
Subject
Reaching
Predicate
NEG_PROCESS_OF
Object
Patients
12. Reaching ASSOCIATED_WITH Chronic disease of respiratory system
Subject
Reaching
Predicate
ASSOCIATED_WITH
Object
Chronic disease of respiratory system
ABSTRACT

BACKGROUND:

Chronic respiratory diseases (CRD) are common among patients with coronavirus disease 2019 (COVID-19).

OBJECTIVES:

We sought to determine the association between CRD (including disease overlap) and the clinical outcomes of COVID-19.

METHODS:

Data of diagnoses, comorbidities, medications, laboratory results, and clinical outcomes were extracted from the national COVID-19 reporting system. CRD was diagnosed based on International Classification of Diseases-10 codes. The primary endpoint was the composite outcome of needing invasive ventilation, admission to intensive care unit, or death within 30 days after hospitalization. The secondary endpoint was death within 30 days after hospitalization.

RESULTS:

We included 39,420 laboratory-confirmed patients from the electronic medical records as of May 6, 2020. Any CRD and CRD overlap was present in 2.8% and 0.2% of patients, respectively. Chronic obstructive pulmonary disease (COPD) was most common (56.6%), followed by bronchiectasis (27.9%) and asthma (21.7%). COPD-bronchiectasis overlap was the most common combination (50.7%), followed by COPD-asthma (36.2%) and asthma-bronchiectasis overlap (15.9%). After adjustment for age, sex, and other systemic comorbidities, patients with COPD (odds ratio [OR] 1.71, 95% confidence interval [CI] 1.44-2.03) and asthma (OR 1.45, 95% CI 1.05-1.98), but not bronchiectasis, were more likely to reach to the composite endpoint compared with those without at day 30 after hospitalization. Patients with CRD were not associated with a greater likelihood of dying from COVID-19 compared with those without. Patients with CRD overlap did not have a greater risk of reaching the composite endpoint compared with those without.

CONCLUSION:

CRD was associated with the risk of reaching the composite endpoint, but not death, of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article Affiliation country: J.jaip.2021.02.041

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Pulmonary Disease, Chronic Obstructive / COVID-19 Type of study: Etiology study / Observational study / Risk factors Limits: Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article Affiliation country: J.jaip.2021.02.041