Palliative radiation therapy for symptomatic advance breast cancer.

Jacobson, Galia; Kaidar-Person, Orit; Haisraely, Ory; Galper, Shira; Rabin, Tatiana; Dromi Shahadi, Ilanit; Lawrence, Yaacov Richard; Symon, Zvi; Akiva Ben-David, Merav

Jacobson, Galia; Kaidar-Person, Orit; Haisraely, Ory; Galper, Shira; Rabin, Tatiana; Dromi Shahadi, Ilanit; Lawrence, Yaacov Richard; Symon, Zvi; Akiva Ben-David, Merav.

Jacobson G; Radiation Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
Kaidar-Person O; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Haisraely O; Radiation Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel. orit.kaidarperson@sheba.health.gov.il.
Galper S; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. orit.kaidarperson@sheba.health.gov.il.
Rabin T; GROW-School for Oncology and Developmental Biology or GROW (Maastro), Maastricht University, Maastricht, The Netherlands. orit.kaidarperson@sheba.health.gov.il.
Dromi Shahadi I; Radiation Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
Lawrence YR; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Symon Z; Radiation Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
Akiva Ben-David M; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Sci Rep ; 11(1): 5282, 2021 03 05.

Article in English | MEDLINE | ID: covidwho-1118819

ABSTRACT

ABSTRACT

In this study, we evaluated the effectiveness of palliative breast radiation therapy (RT), with single fraction RT compared with fractionated RT. Our study showed that both RT fractionation schemas provide palliation. Single fraction RT allowed for treatment with minimal interference with systemic therapy, whereas fractionated RT provided a more durable palliative response. Due to equivalent palliative response, at our institution we have increasingly been providing single fraction RT palliation during the COVID-19 pandemic.

Subject(s)

Breast Neoplasms/radiotherapy; Electrons/therapeutic use; Neoplasm Recurrence, Local/radiotherapy; Palliative Care/methods; Photons/therapeutic use; Radiodermatitis/epidemiology; Adult; Aged; Aged, 80 and over; Breast/pathology; Breast/radiation effects; Breast Neoplasms/pathology; COVID-19/epidemiology; COVID-19/prevention & control; COVID-19/transmission; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Electrons/adverse effects; Female; Follow-Up Studies; Humans; Infection Control/standards; Middle Aged; Neoplasm Recurrence, Local/pathology; Pandemics/prevention & control; Photons/adverse effects; Radiation Oncology/standards; Radiodermatitis/etiology; Retrospective Studies; Treatment Outcome

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Palliative Care / Radiodermatitis / Breast Neoplasms / Photons / Electrons / Neoplasm Recurrence, Local Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-84872-9

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