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Association between influenza vaccination and hospitalisation or all-cause mortality in people with COVID-19: a retrospective cohort study.
Wilcox, Christopher R; Islam, Nazrul; Dambha-Miller, Hajira.
  • Wilcox CR; Primary Care Research Centre, University of Southampton, Southampton, UK christopher.wilcox@doctors.org.uk.
  • Islam N; Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.
  • Dambha-Miller H; Primary Care Research Centre, University of Southampton, Southampton, UK.
BMJ Open Respir Res ; 8(1)2021 03.
Article in English | MEDLINE | ID: covidwho-1119319
Semantic information from SemMedBD (by NLM)
1. Hospitalization TREATS COVID-19
Subject
Hospitalization
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
3. Hospitalization TREATS Persons
Subject
Hospitalization
Predicate
TREATS
Object
Persons
4. Influenza vaccination status PROCESS_OF Persons
Subject
Influenza vaccination status
Predicate
PROCESS_OF
Object
Persons
5. Influenza vaccination ADMINISTERED_TO Participant
Subject
Influenza vaccination
Predicate
ADMINISTERED_TO
Object
Participant
6. Hospitalization TREATS COVID-19
Subject
Hospitalization
Predicate
TREATS
Object
COVID-19
7. COVID-19 PROCESS_OF Persons
Subject
COVID-19
Predicate
PROCESS_OF
Object
Persons
8. Hospitalization TREATS Persons
Subject
Hospitalization
Predicate
TREATS
Object
Persons
9. Influenza vaccination status PROCESS_OF Persons
Subject
Influenza vaccination status
Predicate
PROCESS_OF
Object
Persons
10. Influenza vaccination ADMINISTERED_TO Participant
Subject
Influenza vaccination
Predicate
ADMINISTERED_TO
Object
Participant
ABSTRACT

INTRODUCTION:

Recent evidence suggests that influenza vaccination may offer protection against COVID-19 severity. Our aim was to quantify the association between influenza vaccination status and risk of hospitalisation or all-cause mortality in people diagnosed with COVID-19.

METHODS:

A retrospective cohort study using routinely collected health records from patients registered to a General Practitioner (GP) practice in South West England within the Electronic Care and Health Information Analytics database. The cohort included 6921 people with COVID-19 during the first wave of the pandemic (1 January-31 July 2020). Data on influenza vaccination, hospitalisation and all-cause mortality were ascertained through linked clinical and demographic records. We applied propensity score methods (stabilised inverse probability of treatment weight) to quantify the association between influenza vaccination status and COVID-19 outcomes (hospitalisation or all-cause mortality).

RESULTS:

2613 (38%) participants received an influenza vaccination between 1 January 2019 and COVID-19 diagnosis. Receipt of influenza vaccination was associated with a significantly lower odds of hospitalisation or all-cause mortality (adjusted OR 0.85, 95% CI 0.75 to 0.97, p=0.02), and 24% reduced odds of all-cause mortality (adjusted OR 0.76, 95% CI 0.64 to 0.90).

DISCUSSION:

Influenza vaccination was associated with a 15%-24% lower odds of severe COVID-19 outcomes. The current UK influenza vaccination programme needs urgent expansion as an integral component of the ongoing response plans to the COVID-19 pandemic.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Influenza Vaccines / Cause of Death / Influenza, Human / COVID-19 / Hospitalization Subject: Influenza Vaccines / Cause of Death / Influenza, Human / COVID-19 / Hospitalization Type of study: Etiology study / Incidence study / Observational study / Risk factors Language: English Clinical aspect: Etiology Year: 2021

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Influenza Vaccines / Cause of Death / Influenza, Human / COVID-19 / Hospitalization Subject: Influenza Vaccines / Cause of Death / Influenza, Human / COVID-19 / Hospitalization Type of study: Etiology study / Incidence study / Observational study / Risk factors Language: English Clinical aspect: Etiology Year: 2021
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