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Characteristics and outcomes of 231 COVID-19 cases admitted at a tertiary facility in India: An observational cohort study.
Kumar, Rohit; Bhattacharya, Bisakh; Meena, Ved Prakash; Aggarwal, Anivita; Tripathi, Manasi; Soneja, Manish; Mittal, Ankit; Singh, Komal; Gupta, Nishkarsh; Garg, Rakesh Kumar; Ratre, Brajesh Kumar; Kumar, Balbir; Bhopale, Shweta Arun; Tiwari, Pavan; Verma, Ankit; Bhatnagar, Sushma; Mohan, Anant; Wig, Naveet; Guleria, Randeep.
  • Kumar R; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Bhattacharya B; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Meena VP; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Aggarwal A; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Tripathi M; Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India.
  • Soneja M; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Mittal A; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Singh K; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Gupta N; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Garg RK; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Ratre BK; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Kumar B; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Bhopale SA; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Tiwari P; Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Verma A; Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
  • Bhatnagar S; Department of Onco-anesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Mohan A; Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
  • Wig N; Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
  • Guleria R; Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India.
J Family Med Prim Care ; 9(12): 6267-6272, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1120275
ABSTRACT

BACKGROUND:

Ongoing pandemic because of COVID-19 has spread across countries, with varied clinical features and severity. Awareness of clinical course among asymptomatic and symptomatology in symptomatic cases is essential for patients' management as well as optimal utilization of health services (in resource limited settings) based on clinical status and risk factors. This study aimed to describe the clinical characteristics and outcomes of patients admitted with COVID-19 illness in the initial phase of the pandemic in India.

METHODS:

It was an observational study. Patients aged 18 years or more, with confirmed SARS-CoV-2 infection, asymptomatic or mildly ill, were included. Patients with moderate-severe disease at admission or incomplete clinical symptomatology records were excluded. Data regarding demography, comorbidities, clinical features and course, treatment, results of SARS-CoV-2 RT-PCR, chest radiographs, and laboratory parameters were obtained retrospectively from hospital records. The outcome was noted in terms of course, patients discharged, still admitted (at the time of the study), or death.

RESULTS:

Out of 231 cases, most were males (78.3%) with a mean age of 39.8 years. Comorbidities were present in 21.2% of patients, diabetes mellitus and hypertension being the most common. The most common symptoms were dry cough (81, 35%), fever (64, 27.7%), sore throat (36, 15.6%); asymptomatic infection noted in 108 (46.8%) patients. The presence of comorbidities was an independent predictor of symptomatic disease (OR-2.66; 95%CI 1.08-6.53, P = 0·03). None of the patients progressed to moderate-severe COVID-19, and there were no deaths.

CONCLUSIONS:

A large proportion of patients remained asymptomatic whereas those with comorbidities were more likely to be symptomatic. Most with mild disease had a stable disease course, barring few complication in those with comorbidities. The pandemic continues to grow as large number of asymptomatic cases may go undiagnosed.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: J Family Med Prim Care Year: 2020 Document Type: Article Affiliation country: Jfmpc.jfmpc_1198_20

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: J Family Med Prim Care Year: 2020 Document Type: Article Affiliation country: Jfmpc.jfmpc_1198_20