Management of COVID-19 infection in organic acidemias.
Am J Med Genet A
; 185(6): 1854-1857, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1121487
ABSTRACT
The COVID-19 pandemic has affected the health and healthcare of individuals of all ages worldwide. There have been multiple reports and reviews documenting a milder effect and decreased morbidity and mortality in the pediatric population, but there have only been a small number of reports discussing the SARS-CoV-2 infection in the setting of an inborn error of metabolism (IEM). Here, we report two patients with underlying metabolic disorders, propionic acidemia and glutaric aciduria type 1, and discuss their clinical presentation, as well as their infectious and metabolic management. Our report demonstrates that individuals with an underlying IEM are at risk of metabolic decompensation in the setting of a COVID-19 infection. The SARS-CoV-2 virus does not appear to cause a more severe metabolic deterioration than is typical.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Brain Diseases, Metabolic
/
Glutaryl-CoA Dehydrogenase
/
Propionic Acidemia
/
SARS-CoV-2
/
COVID-19
/
Amino Acid Metabolism, Inborn Errors
Type of study:
Case report
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Infant
Language:
English
Journal:
Am J Med Genet A
Journal subject:
Genetics, Medical
Year:
2021
Document Type:
Article
Affiliation country:
Ajmg.a.62161
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