Your browser doesn't support javascript.
Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm.
Song, Na; Wakimoto, Hiroaki; Rossignoli, Filippo; Bhere, Deepak; Ciccocioppo, Rachele; Chen, Kok-Siong; Khalsa, Jasneet Kaur; Mastrolia, Ilenia; Samarelli, Anna Valeria; Dominici, Massimo; Shah, Khalid.
  • Song N; Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, Massachusetts, USA.
  • Wakimoto H; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Rossignoli F; Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, Massachusetts, USA.
  • Bhere D; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Ciccocioppo R; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Chen KS; Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, Massachusetts, USA.
  • Khalsa JK; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Mastrolia I; Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, Massachusetts, USA.
  • Samarelli AV; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Dominici M; Gastroenterology Unit, Department of Medicine, A.O.U.I. Policlinico G.B. Rossi & University of Verona, Verona, Italy.
  • Shah K; Center for Stem Cell Therapeutics and Imaging (CSTI), Harvard Medical School, Boston, Massachusetts, USA.
Stem Cells ; 39(6): 707-722, 2021 06.
Article in English | MEDLINE | ID: covidwho-1121521
Semantic information from SemMedBD (by NLM)
1. Pathogenic organism CAUSES COVID-19
Subject
Pathogenic organism
Predicate
CAUSES
Object
COVID-19
2. Lung LOCATION_OF Respiratory Distress Syndrom
Subject
Lung
Predicate
LOCATION_OF
Object
Respiratory Distress Syndrom
3. Heart Injuries CAUSES Multiple Organ Failure
Subject
Heart Injuries
Predicate
CAUSES
Object
Multiple Organ Failure
4. Intravenous infusion procedures TREATS Inflammation
Subject
Intravenous infusion procedures
Predicate
TREATS
Object
Inflammation
5. Intravenous infusion procedures PREVENTS Pulmonary Fibrosis
Subject
Intravenous infusion procedures
Predicate
PREVENTS
Object
Pulmonary Fibrosis
6. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
7. Mesenchymal Stromal Cells PART_OF Patients
Subject
Mesenchymal Stromal Cells
Predicate
PART_OF
Object
Patients
8. Pathogenic organism CAUSES COVID-19
Subject
Pathogenic organism
Predicate
CAUSES
Object
COVID-19
9. Lung LOCATION_OF Respiratory Distress Syndrome, Adult
Subject
Lung
Predicate
LOCATION_OF
Object
Respiratory Distress Syndrome, Adult
10. Heart Injuries CAUSES Multiple Organ Failure
Subject
Heart Injuries
Predicate
CAUSES
Object
Multiple Organ Failure
11. Intravenous infusion procedures TREATS Inflammation
Subject
Intravenous infusion procedures
Predicate
TREATS
Object
Inflammation
12. Intravenous infusion procedures PREVENTS Pulmonary Fibrosis
Subject
Intravenous infusion procedures
Predicate
PREVENTS
Object
Pulmonary Fibrosis
13. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
14. Mesenchymal Stromal Cells PART_OF Patients
Subject
Mesenchymal Stromal Cells
Predicate
PART_OF
Object
Patients
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic has grown to be a global public health crisis with no safe and effective treatments available yet. Recent findings suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus pathogen that causes COVID-19, could elicit a cytokine storm that drives edema, dysfunction of the airway exchange, and acute respiratory distress syndrome in the lung, followed by acute cardiac injury and thromboembolic events leading to multiorgan failure and death. Mesenchymal stem cells (MSCs), owing to their powerful immunomodulatory abilities, have the potential to attenuate the cytokine storm and have therefore been proposed as a potential therapeutic approach for which several clinical trials are underway. Given that intravenous infusion of MSCs results in a significant trapping in the lung, MSC therapy could directly mitigate inflammation, protect alveolar epithelial cells, and reverse lung dysfunction by normalizing the pulmonary microenvironment and preventing pulmonary fibrosis. In this review, we present an overview and perspectives of the SARS-CoV-2 induced inflammatory dysfunction and the potential of MSC immunomodulation for the prevention and treatment of COVID-19 related pulmonary disease.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Mesenchymal Stem Cells / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Stem Cells Year: 2021 Document Type: Article Affiliation country: Stem.3354

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Mesenchymal Stem Cells / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 Limits: Humans Language: English Journal: Stem Cells Year: 2021 Document Type: Article Affiliation country: Stem.3354