The role of dalbavancin for Gram positive infections in the COVID-19 era: state of the art and future perspectives.
Expert Rev Anti Infect Ther
; 19(9): 1125-1134, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1122062
ABSTRACT
INTRODUCTION:
The COVID-19 pandemic has dramatically challenged the national health systems worldwide in the last months. Dalbavancin is a novel antibiotic with a long plasmatic half-life and simplified weekly administration regimens, thus representing a promising option for the outpatient treatment of Gram-positive infections and the early discharge of hospitalized patients. Dalbavancin is approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). Many preliminary data seem to support its use in other indications, such as osteomyelitis, prosthetic joint infections, and infective endocarditis. AREAS COVERED A search in the literature using validated keywords (dalbavancin, Gram-positive infections, Gram-positive cocci, ABSSSI, intravenous treatment, and long-acting antibiotics) was conducted on biomedical bibliographic databases (PubMed and Embase) from 2004 to 30 September 2020. Results were analyzed during two consensus conferences with the aim to review the current evidence on dalbavancin in Gram-positive infections, mainly ABSSSI, osteomyelitis, and infective endocarditis, highlight the main limitations of available studies and suggest possible advantages of the molecule. EXPERT OPINION The board identifies some specific subgroups of patients with ABSSSIs who could mostly benefit from a treatment with dalbavancin and agrees that the design of homogenous and robust studies would allow a broader use of dalbavancin even in other clinical settings.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Gram-Positive Bacterial Infections
/
Teicoplanin
/
COVID-19
Type of study:
Prognostic study
/
Reviews
Limits:
Animals
/
Humans
Language:
English
Journal:
Expert Rev Anti Infect Ther
Journal subject:
Communicable Diseases
Year:
2021
Document Type:
Article
Affiliation country:
14787210.2021.1894130
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