Sinonasal NUT Carcinoma: Delayed Diagnosis Due to the COVID-19 Pandemic and a Review of the Literature.
Head Neck Pathol
; 15(4): 1409-1414, 2021 Dec.
Article
in English
| MEDLINE | ID: covidwho-1122819
ABSTRACT
NUT carcinoma (NUT-C) is a relatively new malignancy that was recently listed in the 4th edition of the WHO Classification of Head and Neck Tumors in 2017. NUT carcinoma is a rare, aggressive, poorly differentiated carcinoma genetically defined by chromosomal rearrangement of the nuclear protein in testis (NUTM1) gene. The prognosis is extremely poor, with a mean survival < 1 year. Recent publications suggest a multimodality treatment approach. In the existing literature, only a few reports of sinonasal NUT-C have been reported. Sinonasal NUT-C is considered a very rare entity, but because of its recent inclusion as a head and neck malignancy, its true prevalence is unknown. We report the case of a 56-year-old woman with NUT-C of the sinonasal cavities. In the case reported, the coexistence of Coronavirus disease 2019 (COVID-19)-related nasal congestion delayed the diagnosis of NUT-C. Clinical presentation, diagnosis and treatment modalities are discussed together with a review of the literature.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Paranasal Sinus Neoplasms
/
Nuclear Proteins
/
Delayed Diagnosis
/
Squamous Cell Carcinoma of Head and Neck
/
COVID-19
/
Neoplasm Proteins
Type of study:
Case report
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Journal:
Head Neck Pathol
Journal subject:
Neoplasms
/
Pathology
Year:
2021
Document Type:
Article
Affiliation country:
S12105-021-01311-x
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