First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant.
Enferm Infecc Microbiol Clin (Engl Ed)
; 2021 Feb 19.
Article
in English, Spanish
| MEDLINE | ID: covidwho-2307689
ABSTRACT
INTRODUCTION:
A newly identified SARS-CoV-2 variant, VOC202012/01 originating lineage B.1.1.7, recently emerged in the United Kingdom. The rapid spread in the UK of this new variant has caused other countries to be vigilant. MATERIAL ANDMETHODS:
We based our initial screening of B.1.1.7 on the dropout of the S gene signal in the TaqPath assay, caused by the 69/70 deletion. Subsequently, we confirmed the B.1.1.7 candidates by whole genome sequencing.RESULTS:
We describe the first three imported cases of this variant from London to Madrid, subsequent post-arrival household transmission to three relatives, and the two first cases without epidemiological links to UK. One case required hospitalization. In all cases, drop-out of gene S was correctly associated to the B.1.1.7 variant, as all the corresponding sequences carried the 17 lineage-marker mutations.CONCLUSION:
The first identifications of the SARS-CoV-2 B.1.1.7 variant in Spain indicate the role of independent introductions from the UK coexisting with post-arrival transmission in the community, since the early steps of this new variant in our country.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Topics:
Variants
Language:
English
/
Spanish
Year:
2021
Document Type:
Article
Affiliation country:
J.eimc.2021.02.006
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