Lactoferrin: an overview of its main functions, immunomodulatory and antimicrobial role, and clinical significance.
Crit Rev Food Sci Nutr
; 62(22): 6016-6033, 2022.
Article
in English
| MEDLINE | ID: covidwho-1123187
ABSTRACT
Lactoferrin (LF), a glycoprotein found in mucosal secretions, is characterized by a wide range of functions, including immunomodulatory and anti-inflammatory activities. Moreover, several investigations confirmed that LF displays high effectiveness against multiple bacteria and viruses and may be regarded as a potential inhibitor of enveloped viruses, such as presently prevailing SARS-CoV-2. In our review, we discuss available studies about LF functions and bioavailability of different LF forms in in vitro and in vivo models. Moreover, we characterize the potential benefits and side effects of LF use; we also briefly summarize the latest clinical trials examining LF application. Finally, we point potential role of LF in inflammatory bowel disease and indicate its use as a marker for disease severity.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Immunomodulating Agents
/
Lactoferrin
/
Anti-Infective Agents
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Crit Rev Food Sci Nutr
Journal subject:
Nutritional Sciences
Year:
2022
Document Type:
Article
Affiliation country:
10408398.2021.1895063
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