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What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology.
Altulea, Dania; Maassen, Sjors; Baranov, Maksim V; van den Bogaart, G.
  • Altulea D; Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
  • Maassen S; Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
  • Baranov MV; Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
  • van den Bogaart G; Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, the Netherlands.
J Mol Cell Biol ; 13(3): 175-184, 2021 07 06.
Article in English | MEDLINE | ID: covidwho-1123315
ABSTRACT
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Prognostic study Limits: Humans Language: English Journal: J Mol Cell Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jmcb

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / COVID-19 Drug Treatment / Hydroxychloroquine Type of study: Prognostic study Limits: Humans Language: English Journal: J Mol Cell Biol Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: Jmcb