What makes (hydroxy)chloroquine ineffective against COVID-19: insights from cell biology.
J Mol Cell Biol
; 13(3): 175-184, 2021 07 06.
Article
in English
| MEDLINE | ID: covidwho-1123315
ABSTRACT
Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of coronavirus disease (COVID-19). However, despite promising preliminary findings, many clinical trials showed neither significant therapeutic nor prophylactic benefits of CQ and HCQ against COVID-19. Here, we aim to answer the question of why these drugs are not effective against the disease by examining the cellular working mechanisms of CQ and HCQ in prevention of SARS-CoV-2 infections.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chloroquine
/
COVID-19 Drug Treatment
/
Hydroxychloroquine
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Mol Cell Biol
Journal subject:
Molecular Biology
Year:
2021
Document Type:
Article
Affiliation country:
Jmcb
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