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Susceptibility of Midge and Mosquito Vectors to SARS-CoV-2.
Balaraman, Velmurugan; Drolet, Barbara S; Gaudreault, Natasha N; Wilson, William C; Owens, Jeana; Bold, Dashzeveg; Swanson, Dustin A; Jasperson, Dane C; Noronha, Leela E; Richt, Juergen A; Mitzel, Dana N.
  • Balaraman V; Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA.
  • Drolet BS; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Gaudreault NN; Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA.
  • Wilson WC; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Owens J; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Bold D; Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA.
  • Swanson DA; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Jasperson DC; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Noronha LE; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
  • Richt JA; Department of Diagnostic Medicine/Pathobiology and Center of Excellence for Emerging and Zoonotic Animal Diseases, College of Veterinary Medicine, Kansas State University, 1800 Denison Ave, Manhattan, KS 66506, USA.
  • Mitzel DN; United States Department of Agriculture, Agricultural Research Service, Arthropod-Borne Animal Diseases Research Unit, 1515 College Ave, Manhattan, KS 66502, USA.
J Med Entomol ; 58(4): 1948-1951, 2021 07 16.
Article in English | MEDLINE | ID: covidwho-1123316
ABSTRACT
SARS-CoV-2 is a recently emerged, highly contagious virus and the cause of the current COVID-19 pandemic. It is a zoonotic virus, although its animal origin is not clear yet. Person-to-person transmission occurs by inhalation of infected droplets and aerosols, or by direct contact with contaminated fomites. Arthropods transmit numerous viral, parasitic, and bacterial diseases; however, the potential role of arthropods in SARS-CoV-2 transmission is not fully understood. Thus far, a few studies have demonstrated that SARS-CoV-2 replication is not supported in cells from certain insect species nor in certain species of mosquitoes after intrathoracic inoculation. In this study, we expanded the work of SARS-CoV-2 susceptibility to biting insects after ingesting a SARS-CoV-2-infected bloodmeal. Species tested included Culicoides sonorensis (Wirth & Jones) (Diptera Ceratopogonidae) biting midges, as well as Culex tarsalis (Coquillett) and Culex quinquefasciatus (Say) mosquitoes (Diptera Culicidae), all known biological vectors for numerous RNA viruses. Arthropods were allowed to feed on SARS-CoV-2-spiked blood and at a time point postinfection analyzed for the presence of viral RNA and infectious virus. Additionally, cell lines derived from C. sonorensis (W8a), Aedes aegypti (Linnaeus) (Diptera Culicidae) (C6/36), Cx. quinquefasciatus (HSU), and Cx. tarsalis (CxTrR2) were tested for SARS-CoV-2 susceptibility. Our results indicate that none of the biting insects, nor the insect cell lines evaluated support SARS-CoV-2 replication, suggesting that these species are unable to be biological vectors of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ceratopogonidae / Mosquito Vectors / SARS-CoV-2 / Culicidae Type of study: Experimental Studies Limits: Animals Language: English Journal: J Med Entomol Year: 2021 Document Type: Article Affiliation country: Jme

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ceratopogonidae / Mosquito Vectors / SARS-CoV-2 / Culicidae Type of study: Experimental Studies Limits: Animals Language: English Journal: J Med Entomol Year: 2021 Document Type: Article Affiliation country: Jme