Your browser doesn't support javascript.
Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts.
Suchard, Melinda S; Savulescu, Dana M.
  • Suchard MS; Chemical Pathology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
  • Savulescu DM; Centre for Vaccines and Immunology, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa.
FEBS J ; 289(4): 955-964, 2022 02.
Article in English | MEDLINE | ID: covidwho-1123551
ABSTRACT
Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD+ supplies. We hypothesize that an insufficient cellular NAD+ supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Niacinamide / Sepsis / Energy Metabolism / COVID-19 / Macrophages Type of study: Experimental Studies Topics: Long Covid Limits: Animals / Humans Language: English Journal: FEBS J Journal subject: Biochemistry Year: 2022 Document Type: Article Affiliation country: Febs.15807

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Niacinamide / Sepsis / Energy Metabolism / COVID-19 / Macrophages Type of study: Experimental Studies Topics: Long Covid Limits: Animals / Humans Language: English Journal: FEBS J Journal subject: Biochemistry Year: 2022 Document Type: Article Affiliation country: Febs.15807