An immune epigenetic insight to COVID-19 infection.
Epigenomics
; 13(6): 465-480, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-1123737
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 is a positive-sense RNA virus, a causal agent of ongoing COVID-19 pandemic. ACE2R methylation across three CpG sites (cg04013915, cg08559914, cg03536816) determines the host cell's entry. It regulates ACE2 expression by controlling the SIRT1 and KDM5B activity. Further, it regulates Type I and III IFN response by modulating H3K27me3 and H3K4me3 histone mark. SARS-CoV-2 protein with bromodomain and protein E mimics bromodomain histones and evades from host immune response. The 2'-O MTases mimics the host's cap1 structure and plays a vital role in immune evasion through Hsp90-mediated epigenetic process to hijack the infected cells. Although the current review highlighted the critical epigenetic events associated with SARS-CoV-2 immune evasion, the detailed mechanism is yet to be elucidated.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Epigenesis, Genetic
/
Immune Evasion
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Epigenomics
Year:
2021
Document Type:
Article
Affiliation country:
Epi-2020-0349
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